A5004192937- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Antifungal resistance and susceptibility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial biofilms and quorum sensing
University of Tübingen
2020-2023
German Center for Infection Research
2020-2023
The pandemic of antibiotic resistance represents a major human health threat demanding new antimicrobial strategies. Multiple peptide factor (MprF) is the synthase and flippase phospholipid lysyl-phosphatidylglycerol that increases virulence methicillin-resistant Staphylococcus aureus (MRSA) other pathogens to cationic host defense peptides antibiotics. With aim design MprF inhibitors could sensitize MRSA agents support clearance staphylococcal infections with minimal selection pressure, we...
The success of Staphylococcus aureus as a major cause for endovascular infections depends on effective interactions with blood-vessel walls. We have previously shown that S. uses its wall teichoic acid (WTA), surface glycopolymer, to attach endothelial cells. However, the WTA receptor remained unknown. show here oxidized low-density lipoprotein 1 (LOX-1) interacts and permits binding human Purified LOX-1 bound isolated WTA. Ectopic expression led increased wild type but not WTA-deficient...
Abstract The pandemic of antibiotic resistance represents a major human health threat demanding new antimicrobial strategies. MprF is the synthase and flippase phospholipid lysyl-phosphatidylglycerol that increases virulence methicillin-resistant Staphylococcus aureus (MRSA) other pathogens to cationic host defense peptides antibiotics. With aim design inhibitors could sensitize MRSA both, antimicrobials antibiotics support clearance staphylococcal infections with minimal selection pressure,...