A5095891653- Surgical Simulation and Training
- Anatomy and Medical Technology
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- History of Medicine Studies
- Neurofibromatosis and Schwannoma Cases
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- History of Medical Practice
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Artificial Intelligence in Healthcare and Education
- Advanced Vision and Imaging
- Neuroblastoma Research and Treatments
- Augmented Reality Applications
- Ultrasound in Clinical Applications
- Esophageal Cancer Research and Treatment
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Vascular Malformations and Hemangiomas
- Sarcoma Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Autopsy Techniques and Outcomes
St. Joseph's Hospital and Medical Center
2024-2025
Barrow Neurological Institute
2024-2025
National Cancer Institute
2025
National Institutes of Health
2025
Center for Cancer Research
2025
OBJECTIVE Because gliomas have poorly defined tumor margins, the ability to achieve maximal resection is limited. To better discern these fluorescence-guided surgery has been used aid safe resection. The authors describe their experience with simultaneous use of intraoperative fluorescein sodium (FNa) confocal laser endomicroscopy (CLE) and operating microscope 5-aminolevulinic acid (5-ALA) fluorescence imaging for glioma improve CLE margin discrimination. METHODS FNa 5-ALA wide-field were...
For decades, endovascular embolization (EE) has been a common technique for the treatment of several vascular abnormalities where affected vessel is occluded using biocompatible embolic agents. In this work, we developed NIPAAm-based temperature responsive, dual-crosslinking and non-toxic injectable hydrogel system as liquid agent EE. The swelling mechanical properties were tuned optimized its in vivo application. study was carried out with nine swine models, including three animals...
Transcranial low-intensity focused ultrasound (FUS) enables noninvasive, targeted, and reversible blood-brain barrier (BBB) disruption, facilitating drug delivery liquid biopsy of the brain. Using fluorescein sodium (FNa) with macroscopic widefield fluorescence microscopic confocal laser endomicroscopy (CLE) imaging, we assessed BBB permeability after applying a frameless, electromagnetic-guided FUS system in porcine model confirmed established MRI protocol conventional histology. Both FNa...
Objectives Confocal laser endomicroscopy (CLE) is an intraoperative real-time cellular resolution imaging technology that images brain tumor histoarchitecture. Previously, we demonstrated CLE may be interpreted by neuropathologists to determine the presence of infiltration at glioma margins. In this study, assessed neurosurgeons’ ability interpret from margins and compared their assessments those neuropathologists. Methods vivo acquired were previously reviewed CLE-experienced four...
Objective The development of surgical microscope-associated cameras has given rise to a new operating style embodied by hybrid microsurgical and exoscopic operative systems. These platforms utilize specialized camera systems visualize cranial neuroanatomy at various depths. Our study aims understand how different settings in novel exoscope system influence image quality the context neurosurgical procedures. Methods We built an database using captured cadaveric dissection images obtained with...
Anatomic teaching has long informed surgical knowledge, experience, and skills. One tool for that emerged during the Renaissance was fugitive anatomic sheet, which used flap layers to reveal different levels of anatomy. In 1538, Vogtherr introduced first sheets, included illustrations male female figures with a torso paper that, when lifted, revealed internal organs in cartoonish style. The popularity these sheets spurred an increase small print-and-sale workshops. 1543, Vesalius his books...
Surgical approaches that access the posterior temporal bone require careful drilling motions to achieve adequate exposure while avoiding injury critical structures.
Abstract Background: Patients with Neurofibromatosis Type 1 (NF1) frequently develop benign tumors called Plexiform neurofibromas (PN). Macrophages compose 30-50% of the total cellular composition PNs and have previously been shown to play a critical role in PN development growth. This study defines components immunogenic synapse between neoplastic Schwann cell tumor associated myeloid compartment investigates alterations during treatment MEK inhibition (MEKi). The IL34-CSF1R axis is...