A5108055113- Pancreatic function and diabetes
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- Xenotransplantation and immune response
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Diabetes Management and Research
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Gastroesophageal reflux and treatments
- Cell Image Analysis Techniques
- Parkinson's Disease Mechanisms and Treatments
- Esophageal and GI Pathology
- Pluripotent Stem Cells Research
- Enzyme Structure and Function
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Dental Radiography and Imaging
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- Pancreatic and Hepatic Oncology Research
- Infrared Thermography in Medicine
University of Chicago
2005-2023
University of California, San Diego
2020
Cathay General Hospital
2014
Fu Jen Catholic University
2014
Imaging Center
2011
Laboratoire d’Imagerie Biomédicale
2011
National Chung Hsing University
2010
University of California, Los Angeles
1983-1986
The amounts of simian virus 40 structural polypeptides Vp1, Vp2, and Vp3 in different subcellular fractions at various times after lytic infection were determined by a quantitative immunoblotting procedure. Simian 40-infected cells lysed with buffer containing Nonidet P-40 to yield soluble fraction. P-40-insoluble fraction was further fractionated the presence deoxycholate Tween (cytoskeletal) an insoluble (Nuc), which is primarily cell nuclei. At 33 h postinfection, majority viral proteins...
Abstract Background Detailed knowledge of the molecular and cellular mechanisms that direct spatial temporal gene expression in pre-implantation embryos is critical for understanding control maternal-zygotic transition cell differentiation early embryonic development. In this study, twenty-three clones, expressed at different stages mouse development, were identified using differential display reverse transcription polymerase chain reaction (DDRT-PCR). One these which 2-cell stage 48 hr...
Dental computed tomography (CT) has become a common tool when carrying out dental implants, yet there is little information available on its associated cancer risk. The objective of this study was to estimate the lifetime-attributable risk (LAR) incidence that with radiation dose from CT scans and evaluate effect scan position, sex, age This retrospective cohort involved 505 participants who underwent scans. mean effective doses for male female patients in maxilla group were 408 389 µSv ( P...
Actin and the simian virus 40 viral structural polypeptide Vp1 are observed to be present on cytoskeletal fibers of virus-infected TC7 cells, when these antigens in detergent-extracted whole cell mounts were labeled by specific antibodies colloidal gold particles coated with a second antibody. In both cases, actin found associated fiber-associated electron-dense materials. Patches or clusters denoting presence either uniformly distributed throughout cytoplasm. By using simultaneous...
We reported earlier (Kasamatsu and Nehorayan 1979) that infection of the TC7 subline African green monkey kidney cells with SV40 stimulates appearance staining in centriolar region by preimmune or anti-VP3 sera from rabbits, as observed indirect immunofluorescence. The appears very early infection, prior to T antigen, frequency strong increases rapidly. At 24 hours after a multiplicity 10, about 80% showed positive staining. However, decreases progresses further. stimulation number cellular...
Abstract Introduction Intraluminal esophageal impedance (ILEE) has the potential to measure luminal distension during swallow‐induced peristalsis in esophagus. A cause of inaccuracy ILEE measurement is air bolus. Aim Compare a novel gel bolus current alternatives for impedance‐based (cross‐sectional area, CSA) primary peristalsis. Methods 12 healthy subjects were studied using high‐resolution manometry (HRMZ) and concurrently performed intraluminal ultrasound (US) imaging Three test...
Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets post-gestational hyperglycemia. To prevent these complications, we implemented preemptive supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted optimal blood glucose control pregnancies, preservation graft function postpartum maintenance long-term independence.
Background: Islet after kidney transplantation (IAK) could be an alternative to pancreas transplant in patients with T1DM but clinical outcomes of IAK are inconsistent and the experience is very limited. Here, we present our pilot study islet transplantation, which provided insulin independence optimal blood glucose control. Material: was performed 5 (2-5.5) years initial four at a median age 50(45-59) BMI 25(23-26) HbA1c 8.6(6.8-10.2). Median serum creatinine eGFR were 1.5 (0.9-2.1) 50...
Despite successful treatment of Parkinson's disease (PD) with a wide variety symptomatic therapy, the continues to progress and drug-resistance symptoms become predominant factors producing disability PD patients. Neuroprotective therapies have been tested, but clinically effective drugs not found yet. New insights gained from studies genetic forms point common pathogenic mechanisms that suspected in sporadic may provide new approaches for future neuroprotective therapies.
Background: Total pancreatectomy is a last resort treatment for patients with chronic pancreatitis and intractable abdominal pain, however its utility has been hampered by the uncertain endocrine outcomes of islet transplantation risk postsurgical diabetes. Here, we present our 9-year clinical results after total transplantation. Materials Method: Forty-one or recurrent acute were treated TPIAT over 9 years at University Chicago Medical Center. There 15 male 26 female median age 33 (6-65)...
Background: Anti-thymocyte globulin (ATG) is a potent immunosuppression agent associated with superior long-term islet graft survival compared to anti-IL2R monoclonal antibodies. However, ATG infusion often leads vibrant inflammatory response compromising engraftment after intraportal transplantation. Therefore, we analyzed in relation the timing of anti-thymocyte and transplantation (ITx). Material: In this retrospective single-center study, assessed single allogeneic following groups:...
Background: Islet, as well pancreas transplantations, are alternative procedures providing diabetic patients with insulin independence and optimal blood glucose control. Here, we assessed the utility of islet transplantation after failure a graft in declining function. Materials Methods: Four insulin-deficient diabetes problematic hypoglycemia were transplanted islets allografts prior transplants (IAP). Another four who had previously received allotransplants their function declined (PAI...
Aims: The goal of the study was to assess safety, tolerability and effectiveness prevascularized Sernova Cell Pouch (SCP) for pancreatic islet transplantation. Material: Each 6 patients with T1DM problematic hypoglycemia received 2 cadaveric transplants into SCPs pre-implanted onto muscles abdominal wall. transplant involved open surgical access infusion islets two 8-channel one mini sentinel SCP. Patient thymoglobulin/basiliximab induction, tacrolimus mycophenolate maintenance...