A5048445162- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Urticaria and Related Conditions
- Radiopharmaceutical Chemistry and Applications
- Lysosomal Storage Disorders Research
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Neonatal and fetal brain pathology
Novartis (Switzerland)
2023-2024
Klinik und Poliklinik für Nuklearmedizin
2023
Novartis Institutes for BioMedical Research
2023
Ludwig-Maximilians-Universität München
2023
München Klinik
2023
Ziel/Aim TSPO PET imaging might facilitate monitoring of glioblastoma in preclinical models and patients. However, the detailed cellular non-cellular sources signal remain to be investigated. In this study, we used blocking by excessive cold ligand subsequent cell sorting (scRadiotracing) disentangle magnitude retained blocked tracer single cells compartments glioblastoma.
Ziel/Aim PET targeting the translocator protein (TSPO) emerged as an important tool for in vivo assessment of glioma and serves to detect microglial activation. In this regard, presence remote neuroinflammation is only sparsely understood. Thus, we used translational TSPO imaging investigate whole brain inflammation therapy naïve glioma.
Ziel/Aim Microglial activation is one hallmark in the pathology of lipid storage disease Niemann-Pick type C. It remains unclear if microgliosis caused by lysosomal or as a reactive upregulation to neuronal cell death. Hence, we created knock-out mouse model with specific loss NPC1 microglia and characterized it imaging biomarkers for inflammation synaptic function.