A5016713897- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Aortic aneurysm repair treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Congenital heart defects research
- Cardiac tumors and thrombi
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Lymphatic System and Diseases
- Eicosanoids and Hypertension Pharmacology
- Electrostatic Discharge in Electronics
- Phagocytosis and Immune Regulation
University of Minnesota
2000-2024
University of Minnesota Medical Center
2020-2023
Washington University in St. Louis
2006-2016
Barnes-Jewish Hospital
2006-2014
Jewish Hospital
2006-2014
Society of Thoracic Surgeons
2012
Park Terrace Care Center
2007
Geometric ring annuloplasty has shown promise during bicuspid aortic valve repair for insufficiency. This study examined early outcomes of associated with proximal aneurysm replacement.From September 2017 to November, 2021, 127 patients underwent concomitant reconstruction. Patient age was 50.6 ± 12.7 years (mean standard deviation), male gender 83%, New York Heart Association Class 2 (1-2) (median [interquartile range]), and preoperative insufficiency grade 3 (2-4). Ascending diameter 50...
Abstract The Drosophila Sex Comb on Midleg (SCM) protein is a transcriptional repressor of the Polycomb group (PcG). Although genetic studies establish SCM as crucial PcG member, its molecular role not known. To investigate how might link to complexes, we analyzed in vivo conserved interaction module, SPM domain. This domain found and another protein, Polyhomeotic (PH), which core component repressive complex 1 (PRC1). SCM-PH interactions vitro are mediated by their respective domains. Yeast...
Rheumatic heart disease is the major cause of valvular in developing nations. Endothelial cells (ECs) are considered crucial contributors to rheumatic disease, but greater insight into their roles progression needed.
: Over recent years, a variety of energy sources, including bipolar radiofrequency, have been used to replace the traditional incisions Cox-Maze procedure for surgical treatment atrial fibrillation (AF). The purpose this study was evaluate safety and efficacy novel dual-electrode radiofrequency ablation device Synergy (Atricure, Inc., Cincinnati, OH USA) AF in chronic porcine model.: Six domestic pigs underwent modified IV without cardiopulmonary bypass using device. Animals survived 30...
Abstract Systemic autoantibody-mediated diseases accelerate chronic cardiovascular disease in humans. In the K/B.g7 mouse model of spontaneous inflammatory arthritis, valvular carditis arises part because Fc receptor–mediated activation macrophages, leading to production pathogenic TNF and IL-6. this study, we explored whether impaired efferocytosis mediated by interaction CD47-expressing apoptotic cells with signal regulatory protein α (SIRPα) on macrophages contributes progression model....
The purpose of the present study was to determine for first time qualitative and quantitative impact varying degrees interatrial shunting on right heart dynamics systemic perfusion in subjects with chronic pulmonary hypertension (CPH). Eight dogs underwent 3 mo progressive artery banding, following which atrial ventricular end-systolic end-diastolic pressure-volume relations were calculated using conductance catheters. An 8-mm shunt prosthesis inserted between superior vena cava left atrium,...
Increased right atrial (RA) and ventricular (RV) chamber volumes are a late maladaptive response to chronic pulmonary hypertension. The purpose of the current investigation was characterize early compensatory changes that occur in heart during RV pressure overload before development dilation. Magnetic resonance imaging with radiofrequency tissue tagging performed on dogs at baseline after 10 wk artery banding yield either mild (36% rise pressure; n = 5) or severe (250% 4). free wall divided...
Central MessageA technique was developed to repair calcified bicuspid valves with a subannular annuloplasty ring and autologous aortic wall leaflets. Early clinical echocardiographic results were excellent.See Commentary on page XXX. A excellent. See Aortic valve for young patients insufficiency reparable leaflets is now routine1Miyahara S. Schneider U. Marganthaler L. Schaefers H.-J. (Almost) all nonstenotic should be preserved or repaired.Sem Thoracic Surg. 2019; 31: 656-660Abstract Full...