A5065009623- Autophagy in Disease and Therapy
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Cannabis and Cannabinoid Research
Institut Cochin
2022-2025
Université Paris Cité
2022-2025
Inserm
2022-2025
Centre National de la Recherche Scientifique
2025
La Ligue Contre le Cancer
2022-2025
Abstract Autophagy, a cytoprotective mechanism in intestinal epithelial cells, plays crucial role maintaining homeostasis. Beyond its cell-autonomous effects, the significance of autophagy these cells is increasingly acknowledged dynamic interplay between microbiota and immune response. In context colon cancer, epithelium disruption has been identified as critical factor influencing tumor development. This modulates composition gut microbiota, eliciting an anti-tumoral Here, we report that...
Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway has critical role in the intestine, both during homeostasis and cancer, but remains elusive.We assessed normal intestinal homeostasis, control, epithelial-specific, Axin1-knockout mice (Axin1ΔIEC) Axin2-knockout mice. We evaluated function chemically induced colorectal tumorigenesis dextran sulfate sodium-induced colitis, performed...