A5106708368- Autophagy in Disease and Therapy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Liver physiology and pathology
- 3D Printing in Biomedical Research
- Glycosylation and Glycoproteins Research
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
Universidad de Las Américas
2024-2025
Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, promoting progression through extracellular matrix (ECM) remodeling and paracrine signaling, but signaling pathways controlling CAF function remain incompletely defined. Here, we demonstrate that RAS-PI3K plays a central role in activation ECM by collagen crosslinking, fibronectin organization, glycoprotein deposition at least partially YAP. Disruption interaction CAFs leads to structurally mechanically...
Tracking cell death in vivo can enable a better understanding of the biological mechanisms underlying tissue homeostasis and disease. Unfortunately, existing labeling methods lack compatibility with applications or suffer from low sensitivity, poor penetration, limited temporal resolution. Here, we fluorescently labeled dead cells Trypan Blue (TBlue) to detect single scattered generate whole-mount three-dimensional maps large areas necrotic during organ regeneration. TBlue effectively marked...