A5006246953- Glycosylation and Glycoproteins Research
- Pituitary Gland Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- DNA Repair Mechanisms
- Viral-associated cancers and disorders
- Birth, Development, and Health
- Adrenal and Paraganglionic Tumors
- RNA and protein synthesis mechanisms
- Effects and risks of endocrine disrupting chemicals
- RNA modifications and cancer
- Hypothalamic control of reproductive hormones
- Galectins and Cancer Biology
- Neuroendocrine regulation and behavior
- Genetically Modified Organisms Research
- Carcinogens and Genotoxicity Assessment
- Estrogen and related hormone effects
- Digestive system and related health
- Cancer-related gene regulation
- DNA and Nucleic Acid Chemistry
- Neuroblastoma Research and Treatments
- Polyamine Metabolism and Applications
Medical College of Wisconsin
2024
BioCruces Health research Institute
2017
Universidad de Guadalajara
2006
National Institutes of Health
1984-1986
O-GlcNAcylation is a dynamic modulator of signaling pathways, equal in magnitude to the widely studied phosphorylation. With rapid development tools for its detection at single protein level, O-GlcNAc modification rapidly emerged as novel diagnostic and therapeutic target human diseases. Yet, mapping O-GlcNAcome various tissues essential generating relevant biomarkers. In this study, we used banked tissue sample source identify O-GlcNAcylated targets Using term placentas, propose (1) method...
The inability of the fetal and immature Leydig cell to be desensitized by gonadotropin treatment, a characteristic adult cell, is attributed absence an estrogen-mediated regulation androgen pathway. Cultures rat cells were employed analyze this differential response. revealed low aromatization capacity, undetectable estradiol production, level estrogen receptors, minimally detectable estradiol-regulated protein. However, exogenous caused up-regulation its own receptor, increase protein,...
The receptors and actions of gonadotropin-releasing hormone (GnRH) were analyzed in cultured testicular cells from 20.5-day fetal rats, which treatment with luteinizing (LH) maintained Leydig cell steroidogenesis gonadotropic responses for up to 2 weeks. Testicular GnRH present on the 5th postnatal day, but not demonstrable testes or 2-day cultures thereof. However, readily detectable 4-day increased by exposure agonists. In LH-treated cultures, sites reduced about 50% did increase during...
<title>Abstract</title> Purpose Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph somatotroph PA associate a high clinical burden, despite improved surgical outcomes medical treatment options, sometimes require multiple surgeries radiation. Preliminary data suggested role <italic>O</italic>-GlcNAc Transferase (OGT), enzyme responsible for <italic>O</italic>-GlcNAcylation proteins. O-GlcNAcylation...