A5019373437- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Extracellular vesicles in disease
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
National Yang Ming Chiao Tung University
2025
Institute of Biomedical Sciences, Academia Sinica
2022-2024
National Defense Medical College
2023
National Defense Medical Center
2022-2023
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays key role in this process. We previously showed that delaying macrophage recruitment by clodronate liposome (–1d_CL, macrophage-delayed model) impairs neutrophil resolution heart regeneration, even when infiltrating number was restored within first week post injury (Lai et al., 2017). It is thus intriguing learn regenerative property comparing these late macrophages vs. control during...
Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. Although neonatal mammalian regenerate, the underlying molecular mechanisms remain elusive. Herein, comparative transcriptome analyses identify adherens junction protein N-Cadherin as a crucial regulator of CM proliferation/renewal. Its expression correlates positively with mitotic genes shows an age-dependent reduction. is upregulated in mouse heart...
Abstract Despite numerous advances in our understanding of zebrafish cardiac regeneration, an aspect that remains less studied is how regenerating cardiomyocytes invade, and eventually replace, the collagen-containing fibrotic tissue following injury. Here, we provide in-depth analysis process cardiomyocyte invasion using live-imaging histological approaches. We observed close interactions between protruding macrophages at wound border zone, macrophage-deficient irf8 mutant exhibited defects...
Abstract Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays key role in this process. We previously showed that delaying macrophage recruitment by clodronate liposome (CL) treatment compromises neutrophil resolution heart regeneration, even when infiltrating number was restored within first-week post injury (Lai et al., 2017). Here, we examined molecular mechanisms underlying cardiac repair of regenerative PBS-control vs....