A5012798474- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Congenital heart defects research
- Extracellular vesicles in disease
- Physiological and biochemical adaptations
- Cardiac Structural Anomalies and Repair
- Mechanisms of cancer metastasis
- Tissue Engineering and Regenerative Medicine
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
National Taiwan University
2024-2025
National Taiwan University Hospital
2025
Institute of Molecular Biology, Academia Sinica
2019
Abstract NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on mitochondrial outer membrane (MOM). Here, we report role in hypoxia-induced mitophagy dependent its active site phosphohistidine but not NDPK function. Mice carrying knock-in mutation Nme3 gene disrupting histidine phosphorylation are vulnerable to ischemia/reperfusion-induced infarction and develop abnormalities cerebellar Our mechanistic analysis reveals that phosphatidic acid (PA) mitochondria...
Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. Although neonatal mammalian regenerate, the underlying molecular mechanisms remain elusive. Herein, comparative transcriptome analyses identify adherens junction protein N-Cadherin as a crucial regulator of CM proliferation/renewal. Its expression correlates positively with mitotic genes shows an age-dependent reduction. is upregulated in mouse heart...
Significance Our study provides significant advances in the understanding of circulating exosomal microRNA (miRNA) animals. Circulating miRNAs mediate communication among tissues and organs. In glia, mature miR-274 is produced secreted to hemolymph target recipient cells, neurons, tracheal cells. We also identified gene sty whose expression down-regulated by target/recipient Downregulation Sty leads upregulation MAPK signaling, thereby promoting growth synaptic boutons branches. Thus,...
Synaptic structure and activity are sensitive to environmental alterations. Modulation of synaptic morphology function is often induced by signals from glia. However, the process which glia mediate responses perturbations such as hypoxia remains unknown. Here, we report that, in mutant for Trachealess (Trh), Drosophila homolog NPAS1 NPAS3, smaller boutons form clusters named satellite appear at larval neuromuscular junctions (NMJs), reduction internal oxygen levels due defective tracheal...
Abstract Secreted exosomal miRNAs mediate inter-organ/tissue communication by downregulating gene expression, thereby modulating developmental and physiological functions. However, the source, route, function have not been formally established for specific miRNAs. Here, we show that glial miR-274 non-cell autonomously modulates growth of synaptic boutons tracheal branches. Whereas precursor was expressed in glia, mature secreted. secretion to circulating hemolymph detected exosomes, a...
Abstract Synaptic structure and activity are sensitive to environmental alterations. Modulation of synaptic morphology function is often induced by signals from glia. However, the process which glia mediate responses perturbations such as hypoxia remains unknown. Here, we report that, in Drosophila trachealess ( trh ) mutant, smaller boutons form clusters named bunch appear at larval neuromuscular junctions (NMJs), reduction internal oxygen levels due defective tracheal branches. Thus,...