A5003455316- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Parasite Biology and Host Interactions
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Cancer Research and Treatments
- Perovskite Materials and Applications
- Helminth infection and control
- Mesenchymal stem cell research
- Parasites and Host Interactions
- Esophageal Cancer Research and Treatment
- Image and Video Quality Assessment
- Quantum Dots Synthesis And Properties
- Video Coding and Compression Technologies
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Insect Resistance and Genetics
- Esophageal and GI Pathology
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Infrared Target Detection Methodologies
- Liver physiology and pathology
University of Chicago
2023-2025
University of Massachusetts Chan Medical School
2007-2024
Shanghai Jiao Tong University
2024
Hebei Normal University of Science and Technology
2018-2024
Anhui University of Science and Technology
2024
Beijing Shijitan Hospital
2023
Xi'an Jiaotong University
2004-2023
UNSW Sydney
2022-2023
Materials Science & Engineering
2020-2023
Peking Union Medical College Hospital
2023
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow–derived cells (BMDCs), which frequently recruited sites injury and inflammation, might also represent a potential source malignancy. We show that although acute injury, or transient parietal cell loss within the stomach do not lead BMDC recruitment, chronic infection C57BL/6 mice with Helicobacter , known carcinogen, induces repopulation BMDCs. Subsequently, these progress through...
Abstract Aging is the single most common risk factor for cancer. Peripheral and marrow-derived stem cells are long lived candidate cancer-initiating cell. Repeated rounds of replication likely required accumulation necessary genetic mutations. Based on facts that mesenchymal (MSC) transform with higher frequency than other cell types, tumors in aged C57BL/6 mice frequently fibrosarcomas, we used a genetically tagged bone marrow (BM) transplant model to show develop MSC-derived fibrosarcomas....
The aim of this study was to explore the association specific microRNAs (miRNAs) with development esophageal cancer (EC) and identify new molecular markers for EC by analyzing expression profiles miRNAs in tissues. paired paracancerous normal tissues were detected bioinformatically analyzed using miRNA assays. outcomes validated real-time polymerase chain reaction. assays revealed a total 60 differentially expressed compared those Among them, 51 had doubled or more than their levels 9 halved...
The ligand assisted reprecipitation (LARP) technique is an accessible and facile method that can synthesize metal halide perovskite nanocrystals (PNCs) under ambient conditions. However, low product yields of less than 30% for LARP its contemporary methods are indicative highly inefficient reactions. In this work we apply the principles green chemistry to synthesizing CsPbBr3 PNCs help address issue. Through these efforts, high ∼70% achieved using stochiometric Cs : Pb precursor ratios. This...
The extensive use of halomethanes (CH3X, X = F, Cl, Br, I) as refrigerants, propellants, and pesticides has drawn serious concern due to their adverse biological atmospheric impact. However, there are currently no portable rapid accurate monitoring systems for detection. This work introduces an approach the selective sensitive detection using photoluminescence spectral shifts in cesium lead halide perovskite nanocrystals. Focusing on iodomethane (CH3I) a model system, it is shown that...
Gas sensors are of great interest to portable and miniaturized sensing technologies with applications ranging from air quality monitoring explosive detection medical diagnostics, but the existing chemiresistive NO
Treatment of parasitic nematode infections in humans and livestock relies on a limited arsenal anthelmintic drugs that have historically reduced parasite burdens. However, resistance (AR) is increasing, little known about the molecular genetic causes for most drugs. The free-living roundworm Caenorhabditis elegans has proven to be tractable model understand AR, where studies led identification targets all major drug classes. Here, we used genetically diverse C . strains perform dose-response...
Patients at the same pathological stage of esophageal cancer (EC) that received surgical therapy by surgeon may have distinct prognoses. The current study aimed to explore possibility differentially- expressed microRNAs (miRNAs) underlying this phenomenon. Samples were collected from EC patients tumor node metastasis (TNM) but with different Paracancerous normal tissues taken as controls. specimens histopathologically analyzed. Differentially-expressed miRNAs analyzed using real-time...
Stromal cells and the extracellular environment are vital to human tumors, influencing growth response therapy. Human tumor cell lines lack stroma transplantation into immunodeficient mice does not allow meaningful analyses of effects on growth. Studies xenografts primary fragments in nude early scid mouse models were constrained by poor accompanied host-versus-graft reactivity, dramatically altering architecture microenvironment. In contrast, severely NOD-scid NOD-Rag1 (null) strains...
Large-eddy simulations (LESs) are known to significantly overestimate entrainment in cloud-topped boundary layers, negatively impacting predictions on cloud mass and cover. This overestimation stems from coarse model resolutions that lead numerical broadening of the layer. While it has been shown direct (DNSs) down-to-centimetre-scale can mitigate this issue, such high not viable for most applications atmospheric sciences. The one-dimensional turbulence (ODT), introduced by Kerstein [1],...
Abstract The host immune response plays a critical role in determining disease manifestations of chronic infections. Inadequate may fail to control infection, although other cases the specific be cause tissue damage and disease. majority patients with infections are infected by more than one organism yet interaction between multiple active is not known, nor impact on outcome clear. Using BALB/c strain mice, we show that Toxoplasma gondii infection Helicobacter felis alters natural T....
Long non-coding RNA (lncRNA) SNHG4 has been shown to be associated with the development of a variety cancers. The purpose this study was investigate effect on cervical cancer (CC) and corresponding mechanism. qRT-PCR used determine expressions miR-148a-3p in CC cell lines tissues. Cell apoptosis proliferation were measured by flow cytometry MTT assay, respectively. interaction between SNHG4, c-Met verified bioinformatics, dual-luciferase reporter gene immunoprecipitation (RIP), growth tumor...
Haemonchus contortus is a critical parasite of goats and sheep. Infection by this blood-feeding gastrointestinal nematode (GIN) has significant health consequences, especially in lambs kids. The developed resistance to virtually all known classes small molecule anthelmintics used treat it, giving rise some areas multidrug resistant parasites that are very difficult control. Thus, new urgently needed. Bacillus thuringiensis (Bt) crystal protein 5B (Cry5B), naturally occurring made bacterium...
Abstract Research Question/Issue We approach the ongoing debate in literature on when and why a female leadership advantage exists context of China. In particular, we examine whether CEOs outperform male state‐owned enterprises (SOEs). Findings/Insights show that SOEs. find increased performance is attributed to improved profitability, capital structure, operating efficiency. The magnitude this gender effect bigger central (CSOEs) than local (LSOEs). results are robust additional tests...
Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations tumor cells or the stromal affect switch from dormancy to malignancy. Gene mutations, p53 within stroma of tumors are associated with a worse clinical prognosis; however, it is not known if these can promote genetically at-risk tissue. To address this question, Apc(Min/+) Rag2(-/-) mice, which have predilection mammary carcinoma (as well as wild-type (wt)...
AIM: To study the potential prognostic role of in esophageal squamous cell carcinoma (ESCC). METHODS:Forty six patients were divided into 2 groups according to postoperative survival time: poor outcome group (28 patients), who showed early metastasis but no recurrence, and died within 1 year after surgery, 12 received chemotherapy treatment that was given happening; good (18 had clinical survived 5 years or more all did not receive any treatment.Total RNA extracted from patients'...
This study aimed to investigate whether the miR-198 expression level is related clinicopathological factors and prognosis of esophageal cancer.MicroRNA was extracted from cancer patients who underwent surgery for assessment using Taqman@ MicroRNA assay. The correlation between features analyzed, significance as a prognostic factor its relationship with survival determined.MicroRNA-198 (miR-198) higher in poor than those good (P < 0.05). Kaplan-Meier analysis results showed that had...