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Nico van der Vis

ORCID: 0009-0006-0069-2205
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About
Contact & Profiles
A5003355980
Research Areas
  • Genomics and Phylogenetic Studies
  • RNA and protein synthesis mechanisms
  • Genomics and Chromatin Dynamics

Leiden University
 2023

Imperial College London
 2023

University College London
 2023

Cardiff University
 2023

Vetenskap I Skolan
 2023

 DNA-bridging by an archaeal histone variant via a unique tetramerisation interface
OPENALEX - Publications 
Sapir Ofer Fabian Blombach Amanda M. Erkelens Declan Barker Zoja Soloviev and 9 more Samuel Schwab Katherine Smollett Dorota Matelska Thomas Fouqueau Nico van der Vis Nicholas A. Kent Konstantinos Thalassinos Remus T. Dame Finn Werner

Abstract In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric on DNA ‘hypernucleosome’ particles of varying sizes with each dimer wrapping 30 bp DNA. These composed canonical variant paralogues, but the function these variants is poorly understood. Here, we characterise structure paralogue MJ1647 from Methanocaldococcus jannaschii has a unique C-terminal extension enabling...

10.1038/s42003-023-05348-2 article EN cc-by Communications Biology 2023-09-22
 DNA-bridging by an archaeal histone variant via a unique tetramerisation interface
OPENALEX - Publications 
Sapir Ofer Fabian Blombach Amanda M. Erkelens Declan Barker Samuel Schwab and 7 more Katherine Smollett Dorota Matelska Thomas Fouqueau Nico van der Vis Nicholas A. Kent Remus T. Dame Finn Werner

Abstract In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric on DNA ‘hypernucleosome’ particles of varying sizes with each dimer wrapping 30 bp DNA. These composed canonical variant paralogues, but the function these variants is poorly understood. Here, we characterise structure paralogue MJ1647 from Methanocaldococcus jannaschii has a unique C-terminal extension enabling...

10.21203/rs.3.rs-2183355/v1 preprint EN cc-by Research Square (Research Square) 2023-01-12
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