Background: There is a growing body of evidence on the potential involvement coagulase-negative Staphylococci (CoNS) in causing urinary tract infections (UTIs). The aim this study was to delineate virulence potential, antimicrobial resistance genes, and sequence types CoNS isolated from patients with UTI symptoms pyuria Tanzania. Methods: more than 125 leucocytes/μL were retrieved, subcultured, whole-genome sequenced. Results: Out 65 isolates, 8 species identified; Staphylococcus...

Abstract Background HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and cause catastrophic neurological complications. In studies in Mwanza, affects ~ 8% healthy outpatients done 1990s have suggested that up 23.5% co-infected patients also neurosyphilis. Methodology This was a cross sectional study which adult HIV infected who were hospitalized attending outpatient Care Treatment Clinic (CTC) interviewed using structured...

Abstract Background Sexually transmitted infections (STIs) is a global health problem with increased risk and morbidities during pregnancy. This study investigated the magnitude of viral STIs among pregnant women from three rural hospitals/clinics providing antenatal care in Mwanza region, Tanzania. Methods Between February May 2018, total 499 were enrolled tested for Human immunodeficiency virus (HIV), Herpes simplex virus-2 (HSV-2), Hepatitis B (HBV) C (HCV) using rapid...

Data on colonization and hospital contamination of carbapenem-resistant Gram-negative bacteria (CR-GNB) are limited in low- middle-income countries. We designed this study to determine the prevalence co-existence carbapenemase genes among CR-GNB isolated from clinical, colonization, environmental samples at a tertiary Mwanza, Tanzania. The modified Hodge test (MHT), combined disk (CDT), double-disk synergy (DDST) were used for phenotypic detection carbapenemases. A multiplex PCR assay was...

The World Health Organisation (WHO) recommends the vaccination against Hepatitis B virus in all infants and children up to age of 18 years. In addition, adults high-risk groups should also be vaccinated. This study investigated prevalence factors associated with Virus (HBV) infections among health professional students city Mwanza, Tanzania order provide data that can assist devising prevention control strategies this special group.A cross-sectional involving Catholic University Allied...

Background: Viral infections such as Human cytomegalovirus (HCMV), Rubella virus (RV) and Herpes simplex virus-2(HSV-2) are implicated in causing adverse pregnancy outcomes with limited data from Africa. Here we report the magnitude of these viruses among women unfavorable (WUP) Mwanza, Tanzania. Methods: A cross sectional study involving 198 WUP was conducted between March June 2019 Mwanza. Enzyme linked immunosorbent assay used to detect HCMV RV IgM IgG antibodies while...

This study investigated seroepidemiology of Leptospira serovars among the dog keepers and their dogs in city Mwanza, Tanzania. A total 205 414 were tested for antibodies using a microscopic agglutination test (MAT). The median age was 26 (inter quartile range (IQR): 17–40) years duration keeping 36 (IQR: 24–120) months. seropositivity (33/205 (16.1%, 95% CI: 11.0–21.1) (66/414 (15.9%, 12.4–19.4) dogs, p = 0.4745. Among (Sokoine, Grippotyphosa, Kenya, Pomona Hebdomadis), most prevalent...

Background: Despite blood transfusion being a lifesaving option, it may be associated with borne infections including human cytomegalovirus(HCMV). The World Health Organization recommends screening of products for HCMV before to pregnant women, neonates and immunocompromised patients. However, this is not routinely practised in many resource limited countries.Objective: This study aimed at determining seroprevalence specific IgM antibodies among volunteered donors the Lake Victoria zone...

Leptospirosis is a zoonotic neglected tropical disease with worldwide distribution caused by the pathogenic spirochetes of genus Leptospira. Despite being widespread in regions, it has never been considered routine diagnostic panel for febrile patients. This study determined seropositivity and factors associated Leptospira antibodies among adult patients Mwanza, Tanzania. The cross-sectional involving 296 attending different outpatient clinics Mwanza region was conducted between May July...

Background: Blood transfusion saves life of patients with severe anaemia. However, blood can transmit blood-borne parasites. Despite malaria being endemic in Tanzania, there is limited information on asymptomatic among donors. This study determined the prevalence and associated factors donors at Lake Zone Victoria Transfusion Centre Mwanza, Tanzania.Methods: A cross-sectional was conducted between March April 2016 without any symptoms malaria. During donation, samples were collected from...

<title>Abstract</title> Introduction: High-risk human-papilloma viruses 16 and 18 (HR-HPV HR-HPV-18) are well known to be associated with carcinoma of the cervix, head neck, penis, anus. Low-risk human papillomaviruses 6 11 (LR-HPV LR 11) infection has been anogenital warts, oral papilloma, laryngeal papillomatosis in children. HPV during pregnancy LR-HPV) increases risk vertical transmission from infected pregnant women unborn The burden HR-HPV type LR-HPV is not documented among attending...

High-risk human-papilloma viruses 16 and 18 (HR-HPV HR-HPV-18) are well known to be associated with carcinoma of the cervix, head neck, penis, anus. Low-risk human papillomaviruses 6 11 (LR-HPV LR 11) infection has been anogenital warts, oral papilloma, laryngeal papillomatosis in children. HPV during pregnancy LR-HPV) increases risk vertical transmission from infected pregnant women unborn The burden HR-HPV type LR-HPV is not documented among attending antenatal clinics (ANC). This study...

Background: Aflatoxin arises from toxigenic Aspergillus species, which infect maize because of improper storage, insufficient drying, extended storage periods, and suboptimal farming practices. This study investigated the aflatoxin contamination in for human consumption within specific markets Mwanza, Tanzania. Methodology: A cross-sectional was conducted June to August 2021. Maize samples were analyzed using ELISA followed by descriptive statistical data analysis. Results: total 90...

Background: Hepatitis B virus is a significant public health concern, especially among high-risk groups such as diabetic patients. infection can lead to serious liver diseases hepatocellular carcinoma and cirrhosis. Precise data on the prevalence of infections in these are crucial for executing targeted interventions aimed at reducing transmission. Here, we report factors associated with patients Mwanza, Tanzania. Methodology: A cross-sectional study involving 177 was conducted between May...

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing disease 2019 (COVID-19) pandemic. Despite fact that it affects all ages and profiles, some evidence shows patients with comorbidities, including diabetes, obesity, hypertension, are likely to be most affected. For chronic diseases, such as human immunodeficiency virus (HIV), information scarce, a few studies from high-income countries. This study reports predictors of SARS-CoV-2...

diagnosis, prevention, and surveillance of diseases relies on high quality laboratory services. However, accessibility availability the services among healthcare facilities remains a serious challenge sub-Saharan African countries. This study investigated preparedness district clinical laboratories for ISO 15189: 2012 accreditation scheme using Stepwise Laboratory Quality Improvement Process towards Accreditation (SLIPTA) checklistin Lake Zone, Tanzania.this descriptive cross-sectional was...

Accuracy in the diagnosis is a key step to identify HIV infected individuals for appropriate management. Insufficient supply of manufacturer´s buffers relation number strips per kit has negative impact on patient´s results hence improper In resource limited settings, some laboratory staff use different substitute which never been validated their reliability. This study aimed at comparing performance 0.85% saline and SD-Bioline buffer detection antibodies. A total 220 whole blood specimens:...

Abstract BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, affects ~8% healthy outpatients, older have suggested up 23.5% co-infected patients also

Urogenital pathogens such as Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis have been reported to cause pyuria, however they are not routinely cultured from urine samples of patients clinically diagnosed urinary tract infections (UTI). In this study, pathogen specific PCR was done identify the urogenital in among UTI with negative routine culture.A cross-sectional study conducted involving 227 archived positive leucocyte esterase but culture...

BACKGROUND: Sickle cell disease (SCD) describes a group of inherited red blood disorders. People with SCD have abnormal haemoglobin (Hb), called Hb S. In all forms SCD, at least one the two genes causes person's body to make countries limited resources, diagnostic technique should be simple and easy perform high sensitivity specificity.METHODS: This study compared paperbased sickle test sodium metabisulfite sickling using electrophoresis as gold standard. It was crosssectional hospitalbased...

Abstract Background: HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, affects ~8% healthy outpatients, older have suggested up 23.5% co-infected patients also neurosyphilis. The study aimed at determining the prevalence syphilis, associated factors among HIV infected attending Bugando Medical Center. Methods: This was cross sectional which...

Abstract Background: HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and cause catastrophic neurological complications. In studies in Mwanza, affects ~8% healthy outpatients done 1990s have suggested that up 23.5% co-infected patients also neurosyphilis. Methodology: This was a cross sectional study which adult HIV infected who were hospitalized attending outpatient Care Treatment Clinic (CTC) interviewed using structured...

Abstract BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, affects ~8% healthy outpatients, older have suggested up 23.5% co-infected patients also

Stillbirth adversely affects pregnancy outcomes in low- and middle-income countries (LMICs). Viral infections have been implicated as one of the causes stillbirths. Despite high rates stillbirths viral prevalence LMICs, there is limited information regarding their association. This study investigated magnitude herpes simplex 2 virus (HSV-2) human cytomegalovirus (HCMV) among women with macerated stillbirth.A cross-sectional hospital-based was conducted involving 279 stillbirth between July...