A5049722680- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Parasites and Host Interactions
- Global Maternal and Child Health
- Hepatitis B Virus Studies
- Dermatological diseases and infestations
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Outbreaks Research
- Syphilis Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Parasitic Diseases Research and Treatment
- Pneumonia and Respiratory Infections
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- Neutropenia and Cancer Infections
- Parasite Biology and Host Interactions
- Veterinary medicine and infectious diseases
- Child Nutrition and Water Access
Deutsche Lepra- und Tuberkulosehilfe
2017-2024
Medical Mission Institute
2015-2024
Netherlands Leprosy Relief
2019
German Medical Association
2017
University of Würzburg
2011-2016
Ankara University
2011
Institute of Medical Microbiology and Hygiene
1994
University of Tübingen
1994
United States Food and Drug Administration
1994
Sub-Saharan Africa has a high prevalence of hepatitis B virus (HBV) infections. Health care workers (HCWs) are at risk contracting HBV infection through their occupation. Vaccination HCWs against is standard practice in many countries, but often not implemented resource-poor settings. We aimed with this cross-sectional study to determine prevalence, HCW vaccination status, and the factors for Tanzania. enrolled 600 from tertiary Tanzanian hospital. Their demographics, medical histories,...
A high proportion of grade 2 disability (visible deformity) is indicative delay in detection leprosy and one the major causes preventable disability. We conducted this study to determine risk factors associated with (G2D G1D) among adult new cases measure their strength association.
Background The World Health Organization has called for the elimination of schistosomiasis as a public health problem by 2030 through expanding praziquantel delivery to all community members, specifically targeting foci disease. current project is responding this call implementing community-based mass preventive chemotherapy (PC) an at-risk adult population on Ukerewe Island, northwestern Tanzania. To date, three rounds have been implemented and here we report effect these treatment...
To determine the average time in months between beginning of symptoms and diagnostic confirmation leprosy by health system to investigate factors associated with delay.A total 249 patients older than 15 years diagnosed 2011 2015, 20 endemic municipalities north-eastern Colombia, provided informed consent were interviewed face-to-face. Clinical histories from centres or hospitals where study participants treated for also reviewed.The mean delay diagnosis was 33.5 months. About 14.9% showed a...
Background Schistosomiasis remains one of the most prevalent parasitic infections in world and has significant economic public health consequences, particularly poor communities. Reliable accurate diagnosis plays a key role surveillance, prevention control schistosomiasis. Currently, microscopic Kato Katz (KK) stool thick smear technique is commonly used method to diagnose Schistosoma mansoni epidemiological surveys. It well-known that sensitivity this parasitological decreases when...
Background The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey resource-limited countries. Eligibility criteria patients include age below 25 years in order to focus on the prevalence of transmitted HIVDR (tHIVDR) newly-infected individuals. Most participating sites across Africa have so far reported tHIVDR prevalences 5%. In this study we investigated whether rate <25 is representative rest therapy-naïve population. Methods and Findings...
Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there unacceptably high treatment gap of 62.1% between cases estimated detected. Therefore calls more aggressive close gap. We aimed determine magnitude predictors bacteriologically-confirmed pulmonary among household contacts index city Mwanza, Tanzania. This study was carried out from August...
Leprosy, or Hansen's disease, remains a cause of preventable disability. Early detection, treatment and prevention are key to reducing transmission. Post-exposure prophylaxis with single-dose rifampicin (SDR-PEP) reduces the risk developing leprosy when administered screened contacts patients. This has been adopted in WHO guidelines. The PEP4LEP study aims determine most effective feasible method screening people at administering chemoprophylaxis contribute interrupting
Background Leprosy or Hansen’s disease is known to cause disability and disfigurement. A delay in case detection of leprosy patients can lead severe outcomes. In Ethiopia, the rates caused by among new cases are relatively high compared other endemic countries. This suggests existence hidden community a timely detection. To reduce rates, it crucial identify factors associated with this delay. study aimed determine extent Eastern Ethiopia. Methods cross-sectional explorative was conducted...
Helicobacter pylori (H.pylori) infection is a common medical problem in resource limited areas. The treatment outcome after triple therapy has not been well studied developing countries and preliminary data suggests high rate of failure. This study investigated the failure associated factors among dyspeptic patients receiving H. first line at tertiary hospital, Tanzania.A prospective Gastroenterology unit Bugando Medical Centre (BMC) was conducted between October 2015 May 2017. All with...
Background Delay in case detection is a risk factor for developing leprosy-related impairments, leading to disability and stigma. The objective of this study was develop questionnaire determine the leprosy delay, defined as period between first signs disease moment diagnosis, calculated total number months. instrument developed part PEP4LEP project, large-scale intervention which determines most effective way implement integrated skin screening post-exposure prophylaxis with single-dose...
To achieve zero leprosy cases in Santa Cruz, Bolivia, we designed a community-based active detection and provision of single-dose rifampicin post-exposure prophylaxis (SDR-PEP) to household contacts with new patients.
Innovative approaches are required to further enhance leprosy control, reduce the number of people developing leprosy, and curb transmission. Early case detection, contact screening, chemoprophylaxis currently is most promising approach achieve this goal. The Leprosy Post-Exposure Prophylaxis (LPEP) programme generates evidence on feasibility integrating tracing single-dose rifampicin (SDR) administration into routine control activities in different settings. LPEP implemented within...
Abstract Background Tanzania has a high prevalence (7.17%) of chronic hepatitis B infection. Mother to Child transmission is very common, resulting in rate infections. Currently, there no screening program for HBV pregnant women. This study investigated the and risk factors infection women tertiary hospital Mwanza, Tanzania. Methods Seven hundred forty-three attending antenatal care and/or delivering at Bugando Medical Centre were enrolled. All answered questionnaire on sociodemographic...
Research on the needs of people with disability is scarce, which promotes inadequate programs. Community Based Inclusive Development interventions aim to promote rights but demand a high level community participation. This study aimed identify prioritized as well lessons learned for successful project implementation in different Latin American communities.This was based conducted from 2018 2021 led by Columbian team Columbia, Brazil and Bolivia. Within sequential mixed methods design, we...
Background Sub-therapeutic and supra-therapeutic plasma concentrations of antriretrovirals are the significant causes treatment failure toxicity respectively among HIV-infected patients. We conducted this study to determine pattern efavirenz nevirapine drug adult patients with immunological attending at a tertiary hospital in North-western Tanzania. Materials Methods A cross-sectional was who have been on either or based antiretroviral regimen for more than 6 months. Patients were serially...
Background HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease in antiretroviral-untreated patients. Methods Double-blind, placebo-controlled randomized clinical trial including 326 HIV-patients a resource-limited setting Tanzania (clinicaltrials.gov NCT01299948). Inclusion criteria were CD4 count above 300 cells/μl, the absence of AIDS-defining symptoms and an ART-naïve therapy status. Study participants...
The Leprosy Post-Exposure Prophylaxis (LPEP) program explored the feasibility and impact of contact tracing provision single dose rifampicin (SDR) to eligible contacts newly diagnosed leprosy patients in Brazil, India, Indonesia, Myanmar, Nepal, Sri Lanka Tanzania. As programme is difficult establish short term, we apply mathematical modelling predict its long-term on incidence. individual-based model SIMCOLEP was calibrated validated historic incidence data study areas. For each area,...
Use of laboratory evidence-based patient health care in Tanzania remains a complex problem, as with many other countries sub-Saharan Africa. As at 2010, 39 African countries, including Tanzania, had no clinical laboratories that met the minimum requirements for international standards (International Organization Standardization [ISO] 15189).The aim this article is to share experience from Bugando Medical Centre laboratory's milestones reaching ISO 15189 accreditation.Mentors address...