A5071679574- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Advanced X-ray and CT Imaging
- Radiation Therapy and Dosimetry
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Analysis
- Advances in Oncology and Radiotherapy
- Cardiac pacing and defibrillation studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Obstructive Sleep Apnea Research
- Economic and Financial Impacts of Cancer
- Multiple and Secondary Primary Cancers
- AI in cancer detection
- Cardiovascular and Diving-Related Complications
- Medical Imaging and Pathology Studies
- Anatomy and Medical Technology
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Surgical Treatments
Maastricht University Medical Centre
2019-2024
Maastro Clinic
2019-2024
Maastricht University
2020-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2018
In radiotherapy, automatic organ-at-risk segmentation algorithms allow faster delineation times, but clinically relevant contour evaluation remains challenging. Commonly used measures to assess contours, such as volumetric Dice Similarity Coefficient (DSC) or Hausdorff distance, have shown be good for geometric similarity, do not always correlate with clinical applicability of the time needed adjust them. This study aimed evaluate correlation new and commonly time-saving during...
Purpose Imaging phantoms are widely used for testing and optimization of imaging devices without the need to expose humans irradiation. However, commercially available commonly manufactured in simple, generic forms sizes therefore do not resemble clinical situation many patients. Methods Using 3D printing techniques, we created a life‐size phantom based on CT scan thorax from patient with lung cancer. It was assembled bony structures printed gypsum, consisting airways, blood vessels >1...
Spine stereotactic body radiation therapy (SBRT) requires highly accurate positioning. We report our experience with markerless template matching and triangulation of kilovoltage images routinely acquired during spine SBRT, to determine position.Kilovoltage images, continuously at 7, 11 or 15 frames/s volumetric modulated SBRT 18 patients, consisting 93 fluoroscopy datasets (1 dataset/arc), were analyzed off-line. Four patients immobilized in a head/neck mask, 14 had no immobilization....
Lung tumors treated in breath-hold are subject to inter- and intra-breath-hold variations, which makes tumor position monitoring during each important. A markerless technique is desirable, but limited visibility on kV images this challenging. We evaluated if template matching + triangulation of projection acquired stereotactic treatments could determine 3D position. Band-pass filtering and/or digital tomosynthesis (DTS) were used as image pre-filtering/enhancement techniques. On-board...
Quality of automatic contouring is generally assessed by comparison with manual delineations, but the effect contour differences on resulting dose distribution remains unknown. This study evaluated dosimetric between treatment plans optimized using various organ-at-risk (OAR) methods.OARs twenty lung cancer patients were manually and automatically contoured, after which user-adjustments made. For each set, an automated plan was generated. The intra-observer variation influence variations...
Reducing breathing motion in radiotherapy (RT) is an attractive strategy to reduce margins and better spare normal tissues. The objective of this prospective study (NCT03729661) was investigate the feasibility irradiation non-small cell lung cancer (NSCLC) with visually guided moderate deep inspiration breath-hold (IBH) using nasal high-flow therapy (NHFT).Locally advanced NSCLC patients undergoing photon RT were given NHFT heated humidified air (flow: 40 L/min 80% oxygen) through a cannula....
Treatment quality of proton therapy can be monitored by repeat-computed tomography scans (reCTs). However, manual re-delineation target contours time-consuming. To improve the workflow, we implemented an automated reCT evaluation, and assessed if automatic contour propagation would lead to same clinical decision for plan adaptation as workflow.This study included 79 consecutive patients with a total 250 reCTs which had been manually evaluated. assess feasibility propagated volumes (CTVs)...
The optimal motion management strategy for patients receiving stereotactic arrhythmia radioablation (STAR) the treatment of ventricular tachycardia (VT) is not fully known. We developed a framework using digital phantom to simulate cardiorespiratory in combination with different strategies gain insight into impact on STAR. 4D XCAT was expanded 17-segment left (LV) model which allowed placement STAR targets standardized regions. Cardiac- and respiratory-binned 4D-CT scans were simulated...
Radiotherapy centers frequently lack simple tools for periodic treatment plan verification and feedback on current quality. It is difficult to measure quality over different years or during the planning process. Here, we implemented assurance (QA) by developing a database of dose-volume histogram (DVH) metrics prediction model. These were used assess automatically optimized plans rectal cancer patients, based cohort analysis.A QA framework was established an overlap volume model predict DVH...
Abstract Objective To evaluate two years of clinical experience with markerless breath-hold liver stereotactic radiotherapy (SBRT) using non-invasive nasal high flow therapy (NHFT) for prolonging and surface guidance (SGRT) monitoring. Methods Heated humidified air was administered via a cannula (40 L/min, 80% oxygen, 34 °C). Patients performed voluntary inspiration breath-holds visual feedback. After training session, 4–5 CT scans were acquired to delineate an internal target volume (ITV)...
Abstract Background Stereotactic arrhythmia radioablation (STAR) is a promising non-invasive therapy for patients with ventricular tachycardia (VT). Accurate identification of the arrhythmogenic volume, or clinical target volume (CTV), on radiotherapy (RT) 4D planning computed tomography (CT) scan key STAR efficacy and safety. This case report illustrates our workflow electro-structural image integration CTV delineation. Case summary A 72-year-old man ischaemic cardiomyopathy VT storm,...
Abstract Background/introduction Noninvasive stereotactic radiotherapy (STAR) is an emerging transmural ablative therapy for refractory ventricular tachycardia (VT). Delineation of the arrhythmogenic gross target volume (GTV) relies on electrical (exit and isthmus) VT characteristics anatomical scar detailing. 17-AHA segmental approaches or eyeballing techniques are adopted to transfer GTV treatment planning CT. An individualized 3D delineated with ADAS3D based areas interest each modality...
Purpose or ObjectiveWe investigate four different rescanning techniques in active proton beam therapy of non-small cell lung cancer (NSCLC), and assess their ability to reduce interplay effects.NSCLC has been identified be well-suited for protons, but the region poses many problems related large density heterogeneities organ motion, including effect. Material MethodsThe investigated are (1) volumetric rescanning, (2) layered (3) breath-sampled (BS) (4) continuous breathsampled (CBS)...