Lakshmi Yarlagadda

ORCID: 0009-0006-0872-8380
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About
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Research Areas
  • Multiple Myeloma Research and Treatments
  • Cancer Treatment and Pharmacology
  • Peptidase Inhibition and Analysis
  • Protein Degradation and Inhibitors
  • Hematopoietic Stem Cell Transplantation
  • Chronic Myeloid Leukemia Treatments
  • Liver Disease Diagnosis and Treatment
  • SARS-CoV-2 and COVID-19 Research
  • Colorectal Cancer Screening and Detection
  • Esophageal and GI Pathology
  • Sex work and related issues
  • COVID-19 Clinical Research Studies
  • Essential Oils and Antimicrobial Activity
  • Cancer therapeutics and mechanisms
  • Infectious Aortic and Vascular Conditions
  • Phytochemistry and Biological Activities
  • Sexuality, Behavior, and Technology
  • Natural product bioactivities and synthesis
  • Immunotherapy and Immune Responses
  • Criminal Justice and Corrections Analysis
  • Diverse Scientific Research Studies
  • COVID-19 Impact on Reproduction
  • Diabetes and associated disorders
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chronic Lymphocytic Leukemia Research

GSL Medical College & General Hospital
2023-2025

University of Arkansas for Medical Sciences
2021-2024

Winthrop Rockefeller Foundation
2021-2022

Southeastern Health
2020

Howard University
2015

Howard University Hospital
2014

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, procedure is overall rare with most patients in US undergoing inpatient ASCT. Furthermore, hospitalization rates that undergo remain high. Adequate markers predict during are lacking, yet would great clinical value select suited In this study we aimed elucidate differences between...

10.3390/jcm11061640 article EN Journal of Clinical Medicine 2022-03-16

Daratumumab, a CD38-targeting monoclonal antibody, has significantly improved survival rates in multiple myeloma (MM), yet patients who progress on Daratumumab have dismal clinical outcomes with an overall median of less than 10 months. While emerging novel modalities shown promising results, the current study explores use high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) heavily pretreated Daratumumab-refractory MM patients. We retrospectively investigated...

10.3390/cancers13164019 article EN Cancers 2021-08-10

Myxopyrum smilacifolium Blume geographical occurrence is southern part of India and its usage for the treatment various diseases has been marked in Traditional Medicine. The present study was aimed to examine phytoconstituents antiarthritic activity by insilico approach. Antiarthritic performed using software Autodock 4.0. For each pharmacokinetic parameters are also assessed online tools. revealed that phytocompounds, Arenarioside, Verbascoside Myxopyroside showed docking score about -16.4...

10.13005/bpj/2851 article EN Biomedical & Pharmacology Journal 2024-03-20

e20031 Background: The advent of novel therapies has significantly improved outcomes in MM, yet most patients will eventually relapse. Patients progressing on CD38-targeting monoclonal antibodies, proteasome inhibitors (PIs) and IMiDs have dismal outcome. While treatment modalities based mechanisms shown promising results, the current study explores use high dose chemotherapy followed by autologous stem cell transplantation (ASCT) these heavily pretreated MM patients. Methods: We...

10.1200/jco.2021.39.15_suppl.e20031 article EN Journal of Clinical Oncology 2021-05-20

Introduction: Having a good bowel preparation is essential for quality colonoscopy. Inpatient status an independent risk factor poor which delays care and increases length of stay. The aim the study was to identify factors associated with inpatient Methods: We reviewed medical records identified patients colonoscopy procedures between August 2011 June 2013. abstracted information on patient characteristics, history, medications, hospital course, preparation. Logistic regression analyses were...

10.14309/00000434-201510001-02332 article EN The American Journal of Gastroenterology 2015-10-01

Introduction: We are reporting a case of aortoesophageal fistula, rare and fatal complication after esophageal stenting for anastomotic leak malignant tumor resection. Very few cases reported so far. A 76-year-old black female admitted to the hospital with diagnosis stage 1 gastric adenocarcinoma underwent gastrectomy roux-en-y esophagojejunostomy. After 3 weeks post op she had abdominal tenderness, CT oral contrast revealed small anastamotic subsequently endoscopy stent was placed. Ten...

10.14309/00000434-201410002-00820 article EN The American Journal of Gastroenterology 2014-10-01

e19215 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in United States. From 2010 to 2014, CRC was also North Carolina (NC). Between 2012-2016, age adjusted mortality rate 18-25 per 100,000 persons Robeson County, NC. During this timeframe, it estimated that if all people aged 50 and older NC were routinely screened, 40 out 100 from late stage can be prevented. A chart review a rural primary care clinic identified patients not being appropriately...

10.1200/jco.2020.38.15_suppl.e19215 article EN Journal of Clinical Oncology 2020-05-20
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