A5101648512- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Advanced Breast Cancer Therapies
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Global Health Workforce Issues
- E-commerce and Technology Innovations
- Chronic Myeloid Leukemia Treatments
- GDF15 and Related Biomarkers
- Global Health and Surgery
- Wnt/β-catenin signaling in development and cancer
- Global Education and Multiculturalism
- Educational Research and Pedagogy
- Adult and Continuing Education Topics
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Connective Tissue Growth Factor Research
Huaiyin Normal University
2025
Sun Yat-sen University
2023-2025
Sun Yat-sen University Cancer Center
2023-2025
State Key Laboratory of Oncology in South China
2023-2025
Xinyang Central Hospital
2022
Fujian Medical University
2016
Union Hospital
2016
Objective Metastasis is the major cause of cancer death. However, what types heterogenous cells in primary tumour and how they metastasise to target organs remain largely undiscovered. Design We performed single-cell RNA sequencing spatial transcriptomic analysis colorectal (CRC) metastases liver (lCRC) or ovary (oCRC). also conducted immunofluorescence staining functional experiments examine mechanism. Results Integrative analyses epithelial reveal a stem-like cell cluster with high protein...
Abstract N 6-Methyladenosine (m6A) is the most prevalent RNA modification and associated with various biological processes. Proteins that function as readers writers of m6A modifications have been shown to play critical roles in human malignancies. Here, we identified KH-type splicing regulatory protein (KHSRP) an binding contributes progression pancreatic ductal adenocarcinoma (PDAC). High KHSRP levels were detected PDAC predicted poor patient survival. deficiency suppressed growth...
In the e-commerce supply chain, transportation cost is one of key factors affecting overall chain cost. Reasonable planning routes and warehousing layout can effectively reduce costs, thereby improving efficiency benefits. Accurate demand forecasting plays a core role in determining appropriate location number sites. greatly enhance decision-making processes such as inventory optimization distribution planning. This paper uses algorithms multi-model ensemble learning to accurately predict...
Under the guidance of new curriculum standards, mathematical abstraction ability is a critical aspect developing students' core literacy. Taking inequalities as an example, this paper explores effective strategies for cultivating high school ability. The are based on practical teaching examples and include guiding students to understand abstract concepts, strengthening expression language, expanding breadth depth thinking, fostering self-reflection. These aim help master concepts...
Background The resistance of pancreatic ductal adenocarcinoma (PDAC) to trametinib therapy limits its clinical use. However, the molecular mechanisms underlying in PDAC remain unclear. Objective We aimed illustrate and identify resistance-associated druggable targets, thus improving treatment efficacy trametinib-resistant PDAC. Design established patient-derived xenograft (PDX) models primary cell lines conduct functional experiments. also applied single-cell RNA sequencing, Assay for...
Abstract The therapeutic options for treating pancreatic ductal adenocarcinoma (PDAC) are limited, and resistance to gemcitabine, a cornerstone of PDAC chemotherapy regimens, remains major challenge. N6-methyladenosine (m6A) is prevalent modification in mRNA that has been linked diverse biological processes human diseases. Herein, by characterizing the global m6A profile panel gemcitabine-sensitive gemcitabine-insensitive cells, we identified key role elevated master G0–G1 regulator FZR1...
<p>Proteins identified in RNA pulldown and mass spectrometry analysis with FZR1[m6A] or FZR1[A].</p>
<p>Supplementary Figures 1-6 and supplementary Tables 1-7.</p>
<p>Proteins identified in RNA pulldown and mass spectrometry analysis with FZR1[m6A] or FZR1[A].</p>
<p>Supplementary Figures 1-6 and supplementary Tables 1-7.</p>
<div>Abstract<p>The therapeutic options for treating pancreatic ductal adenocarcinoma (PDAC) are limited, and resistance to gemcitabine, a cornerstone of PDAC chemotherapy regimens, remains major challenge. N6-methyladenosine (m6A) is prevalent modification in mRNA that has been linked diverse biological processes human diseases. Herein, by characterizing the global m6A profile panel gemcitabine-sensitive gemcitabine-insensitive cells, we identified key role elevated master G0/G1...
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