A5059370234- Primate Behavior and Ecology
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Animal Behavior and Reproduction
- Pharmacological Effects and Assays
- Evolutionary Psychology and Human Behavior
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Animal Behavior and Welfare Studies
- Neuroblastoma Research and Treatments
- Schizophrenia research and treatment
- Cell Image Analysis Techniques
- Diet and metabolism studies
- Animal Vocal Communication and Behavior
- Neural dynamics and brain function
- Glioma Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Advanced MRI Techniques and Applications
- Trace Elements in Health
The University of Texas at Austin
2024-2025
University of California, Los Angeles
1980-1998
West Los Angeles College
1987-1998
Los Angeles Medical Center
1998
Neurobehavioral Systems
1981-1995
VA Sepulveda Ambulatory Care Center
1995
Brentwood Hospital
1984-1991
United States Department of Veterans Affairs
1980-1987
Background/Objectives: Neuroblastoma is a genetically diverse, highly metastatic pediatric cancer accounting for 15% of childhood deaths despite only having ~8% incidence. The current standard care high-risk diseases genotoxic. This, combined with less than 50% survival in and an abysmal 5% relapsed cases, makes discovering novel, effective, toxic treatments essential. Methods: A prophylactic syngeneic mouse model was used to test high-dose lipid-mediator unsaturated fatty acids on...
The present positron emission tomography study used 2-deoxy-2[18F]fluoro-D-glucose to examine age-related changes in local cerebral metabolic rates for glucose (LCMRglc) sedated rhesus macaques and vervet monkeys. Nineteen monkeys were scanned a cross-sectional design, which consisted of three age groups (birth 59 d, 60-179 180 d adult) that captured the developmental period greatest synaptic density within second group. Two two also examined longitudinally. Subjects throughout procedure...
Abstract Among group‐housed male Cercopithecus aethiops , dominant animals have higher concentrations of whole bood serotonin (WBS) than their subordinate counterparts. In contrast, there appears to be no relationship between social status and WBS in Macaca nemestrina . We report here the among 29 fascicularis housed groups five. Membership these was disrupted periodically (20 times 26 months) with a reorganization manipulation. Concentrations were assessed just prior 20th (final) at 1, 2, 5...
Cellular distribution of the Glutl glucose transporter in normal primate brains was analyzed by immunogold electron microscopy. Two configurations endothelial (high and low density capillaries) have been found resections traumatically injured epileptogenic human brain; objective present study to ascertain whether these same 2 capillary populations, expressing high densities, were common configuration brain. The relative numbers transporter- associated gold particles on luminal abluminal cell...
Abstract Neuroblastoma (NB) is a genetically diverse, highly metastatic pediatric cancer that accounts for an estimated 8% of childhood incidence but responsible 15% deaths. High-risk and relapsed cases have less than 50% near 5% survival, respectively. The current standard care genotoxic, resulting in life-long health issues increased risk new incidence. Effective toxic approaches to neuroblastoma remain elusive. We show here ω3 ω6 unsaturated fatty acids (HUFA) differential effects on...
Abstract The worst patient outcomes in neuroblastoma are driven by high-risk disease 1,2 , which is divided into similarly sized MYCN amplified and non-amplified subgroups 3 . Male patients have been reported to slightly worse than females all-patient analyses of multiple studies 3,4 However, we show here that non- stage 4s low-risk disease, female significantly overall survival males. Female highly express H19 DLK1 both drive cell growth vitro associated with but not Further,...
Abstract Neuroblastoma (NB) is a devastating neural crest-derived tumor primarily affects children under five. Forty percent of NB patients are classified as high-risk (HR), and less than half them survive. HR disease split into two equally sized groups: one exhibiting genetic amplification the MYCN proto-oncogene (MA), another where non-amplified (MNon). Overall survival (OS) studies often either poorly annotated or focused on outcomes across entire patient group, which may mask...