A5018292535- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Nanowire Synthesis and Applications
- Erythrocyte Function and Pathophysiology
- Adrenal Hormones and Disorders
- Endoplasmic Reticulum Stress and Disease
- DNA Repair Mechanisms
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Nanoparticle-Based Drug Delivery
- Pancreatic function and diabetes
Centre for Cancer Biology
2022-2025
University of South Australia
2022-2025
South Australia Pathology
2022-2025
Abstract TFEB is a master regulator of autophagy, lysosome biogenesis, mitochondrial metabolism, and immunity that works primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulatory interactions at the surface organelles such as lysosomes. Here we show has non-transcriptional role in mitochondria, regulating electron transport chain complex I to down-modulate inflammation. Proteomics analysis reveals extensive...
Adjuvant chemotherapy is highly recommended for liver cancer to enhance survival rates due its tendency recur frequently. Localized drug-eluting implants have gained traction as an alternative overcome the limitations of systemic chemotherapy. This work describes development biodegradable 3D printed (3DP) bilayer films loaded with 5-fluorouracil (5FU) and cisplatin (Cis) different infill percentages where 5FU layers were 40%, 30%, 30% Cis 10%, 15%, 10% A, B, C, respectively. The relevant...
Abstract Objectives CAR‐T cells are being investigated as a novel immunotherapy for glioblastoma, but clinical success has been limited. We recently described fibroblast activation protein (FAP) an ideal target antigen glioblastoma immunotherapy, with expression on both tumor and blood vessels. However, targeting FAP have never therapy glioblastoma. Methods generated CAR CD3ζ CD28 signalling domains tested the resulting their lytic activity cytokine secretion function in vitro (using...
The regulation of vitamin D3 actions in humans occurs mainly through the Cytochrome P450 24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3), which is first step D catabolism. An abnormal status upregulation many diseases, including chronic kidney disease (CKD). CKD diminished activation contribute to secondary hyperparathyroidism (SHPT), progressive bone deterioration, soft tissue...
Abstract Objectives CAR-T cells are being investigated as a novel immunotherapy for glioblastoma, but clinical success has been limited. We recently described fibroblast activation protein (FAP) an ideal target antigen glioblastoma immunotherapy, with expression on both tumor and blood vessels. However, targeting FAP have never therapy glioblastoma. Methods generated CAR CD3ζ CD28 signaling domains tested the resulting their lytic activity cytokine secretion function in vitro (using...
Abstract TFEB is a master regulator of autophagy, lysosome biogenesis and mitochondrial metabolism that works, immunity, primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulatory interactions at the surface organelles such as lysosomes. Here we show has non-transcriptional role in mitochondria, regulating electron transport chain complex I to down-modulate inflammation. Proteomic analysis revealed extensive co-precipitation...