Severe prolonged migrainous symptoms and partial status epilepticus are characteristic features of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes). Maternal transmission previously found in myoclonus epilepsy ragged-red fibers (MERRF), another mitochondrial disease, is suggested this disorder as well.

Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center multidisciplinary approach can provide the best outcomes. From January 2006 September 2023, bicentric observational was conducted at Plastic Surgery Department of Policlinico Umberto I, Sapienza University Rome, Regenerative San Gallicano Dermatological Institute IRCCS, Italy. Out 6800 cases, twenty pregnant women were selected: thirteen underwent only wide local...

Background: The reconstruction of extensive full-thickness lower eyelid defects constitutes a challenge for plastic surgeons. Various techniques have been described to cater patients' specific defect needs, with the aim achieving best results. Materials and Methods: We performed retrospective observational study assessing our experience combination single-stage procedure consisting hard palate graft Fricke flap patients complex lid resections undergoing immediate total at institution....

Three cases of a heterofore undescribed neoplasm major salivary glands morphologically similar to giant cell tumor bone are presented. All tumors were located in the parotid gland adult individuals, and all patients alive well following surgical excision. One three was associated intimately with malignant mixed (carcinoma pleomorphic adenoma). Ultrastructural immunohistochemical studies failed provide conclusive evidence about specific nature cells. The should be added long list organs which...

Abstract A 16‐year‐old girl, previously in good health, developed progressive generalized muscle weakness following her first parturition. The neck and proximal limb muscles were especially weak painful. Carnitine (4‐trimethylamino‐3‐hydroxybutyrate) was markedly decreased muscle, plasma, urine. Dietary carnitine supplementation, 2.0 gm daily, followed by clinical improvement lipid droplets biopsy. Together with reported cases, 2 fatal, the patient's illness emphasizes risk of pregnancy...

A man with Fabry's disease, who died at 52, suffered from lancinating limb pains between the age of 20 and 27, severe arthralgia 40. The sural nerve showed a loss fibers (1,614 myelinated fibers/mm2), chiefly affecting small fibers. Inclusions both homogeneous lamellated appearance were present in perineurial cells, fibroblasts vessel walls. Teased displayed moderate remyelination, regeneration presence globular focal myelin thickening. transient time course painful manifestations this case...

In four patients, calf muscular hypertrophy developed after the onset of sciatica. Hypertrophic muscles were weak and showed electromyographic signs denervation. all cases, muscle biopsy striking type 1 and, especially, 2 fibers. This was associated with other indicating a neurogenic lesion. Muscle is rare finding in lesions. Stretch exercise are probably causative factors.

The ultrastructural features of 8 human cardiac myxomas were analyzed and correlated with immunohistochemical data, the aim to clarify characteristics cell lines involved in tumor genesis. Immunohistochemical studies performed detect presence distribution intracytoplasmic filaments (vimentin, desmin, actin, myosin) as well myoglobin factor VIII-related antigen, albumin, lysozyme. Eighty percent myxoma cells simultaneously positive for vimentin, whereas 30% them stained antifactor VIII...

The authors report a case of signet ring cell lymphoma, rare variety germinal (follicular) centre neoplasm. Its clinical, histological and ultrastructural findings are compared with those the nine cases previously described. Original immunocytochemical results presented discussed.

• A father and son had benign spinal muscular atrophy syndrome, clinically characterized only by cramps gross hypertrophy of the calves. The electromyogram biopsy specimen indicated a motor neuron disease in both patients. In son, "pseudomyopathic" changes were also observed. To our knowledge, similar cases with calves probable autosomal dominant inheritance have not been previously described.

A primary malignant fibrous histiocytoma of the spleen was studied by light and electron microscopy is believed to be first reported. The neoplasm predominantly fibroblastic, with a characteristic storiform pattern, included histiocyte‐like cells, giant foam cells confirmed ultrastructural studies. Additionally, undifferentiated intermediate myofibroblasts were seen. differential diagnosis from other sarcomas histogenesis this tumour are discussed.

Large multilobated nuclei lymphoma is a rare entity that characterized morphologically by large neoplastic elements with prominent nuclear lobations and clinically predilection for extranodal sites favorable prognosis. According to the data collected date, neoplasia thought be of T-cell origin. The authors describe clinical, morphologic immunohistochemical findings case non-Hodgkin's showed definite B-lymphocyte

A case of progressive external ophthalmoplegia (PEO) in association with peripheral neuropathy and other neural visceral manifestations is reported. Pathological studies the sural nerve demonstrated loss large myelinated fibers, segmental demyelination remyelination, excess zebra bodies Schwann cells on electron microscopy. Peripheral course PEO regarded as a further although rare aspect multisystem disease.

In experimental animal studies, exogenous hyaluronan (HA) has been shown to exert beneficial effects on the healing of tympanic membrane perforation. As any other substance, HA may prove potentially toxic, by filling middle ear cavity, sensory cells organ Corti. Electrophysiological (ABR) and morphological studies were carried out in rat examine auditory function structure epithelium. Rats received either or hydroxy-propyl-methyl-cellulose trans-tympanic injection (middle cavity was...