A5004862194- Biochemical and Molecular Research
- Synthesis and bioactivity of alkaloids
- Synthesis of Indole Derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Advanced Breast Cancer Therapies
- Enzyme Structure and Function
- Bioactive Compounds and Antitumor Agents
- Ovarian cancer diagnosis and treatment
- Adenosine and Purinergic Signaling
- Synthesis and Reactions of Organic Compounds
- Tuberculosis Research and Epidemiology
- Acute Lymphoblastic Leukemia research
- HIV/AIDS drug development and treatment
- Quinazolinone synthesis and applications
MIREA - Russian Technological University
2023-2025
Introduction . Ovarian cancer is one of the most common gynecological cancers worldwide, which difficult to diagnose and treat. high mortality rate from ovarian makes development new therapeutic drugs relevant. Ribavirin (RBV), commonly used antiviral agent, revealed anticancer potential, however, it led severe side effects as well. RBV derivatives were previously synthesized tested putative in models hematological malignancies. The aim this study was estimate (MGs) cells vitro Material...
Ribavirin and its analogues exhibit an in vitro antiproliferative effect cancer cells. In this work we studied the biological activities of a number oxymethyl derivatives ribavirin’s aglycon – 1,2,4-triazole-3-carboxamide. Oxymethyl 1,2,4-triazole-3-carboxamide with substitu-tions at fifth or first position triazole ring, were synthesized their antimicrobial effects assessed. For both series presence was inves-tigated case 1-oxymethyl shown potential against Gram-positive bacteria...
Ribavirin and its analogues exhibit an in vitro antiproliferative effect cancer cells. In this work, we studied the biological activities of a number alkyl/aryloxymethyl derivatives ribavirin’s aglycon—1,2,4-triazole-3-carboxamide. Alkyl/arylxymethyl 1,2,4-triazole-3-carboxamide with substitutions at fifth or first position triazole ring, were synthesized their antimicrobial effects assessed. For both series, presence was investigated, 1-alkyl/aryloxymethyl shown potential against...
Background:: A number of studies demonstrate the efficacy ribavirin against various cancer types in vitro and vivo models. However, induces development multiple side effects, suggesting a high demand for analogues with improved therapeutic indexes. Objective:: This study was focused on analysis ribavirin, its aglycon 1,2,4-triazole-3-carboxamide, several derivatives activities blood cells vitro. Methods:: Four 1,2,4-triazole-3-carboxamide were designed synthesized. Antiproliferative effects...
Glucocorticoids (GC) are widely used in the treatment of hematological malignancies; however, long-term lead to atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRA) with reduced side effects could be better GC alternative. More than 30 SEGRA were described but none them reached clinical trials as anticancer treatment. In present work, we proposed novel approach broaden list potential by synthesis derivatives synephrine, molecule natural origin. We...
Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRAs) reduced side effects may act as a superior alternative GCs. More than 30 SEGRAs have been described so far, yet none of them reached clinical trials for anti-cancer treatment. In the present work, we propose novel approach increase number potential by obtaining derivatives...