A5071332659- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Advanced Technologies in Various Fields
- Mesenchymal stem cell research
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
Qinghai Provincial Peoples Hospital
2019-2024
Qinghai University
2019-2021
Ji, Weizhong, Yaqing Zhang, Ri-li Ge, Yaqi Wan, and Jie Liu. NMDA receptor-mediated excitotoxicity is involved in neuronal apoptosis cognitive impairment induced by chronic hypobaric hypoxia exposure at high altitude. High Alt Med Biol. 22:45–57, 2021. Aim: Exposure to altitude can lead impairment; however, its underlying mechanism still unclear. Excessive expression of glutamate receptors induce cause necrosis, which an important causative factor for the occurrence various diseases nervous...
Abstract Objectives Sequelae of stroke were mainly caused by neuronal injury. Oxygen is a key factor affecting the microenvironment neural stem cells (NSCs), and oxygen levels are used to promote NSC neurogenesis. In this study, effects intermittent hypoxic preconditioning (HPC) on neurogenesis investigated in rat model middle cerebral artery occlusion (MCAO). Methods SD rats establish MCAO model. Nissl staining Golgi confirm injury status Immunofluorescence, transmission electron...
Background: Moderate hypobaric hypoxia induces cerebral ischemic tolerance. We investigated the optimal method for applying preconditioning at 5,000 m to brain tissue and combined it with proteomics determine mechanisms underlying this effect. Methods: Male SD rats were randomly grouped as S (sham, n = 20), M (middle artery occlusion [MCAO], 28), H2M (intermittent preconditioned MCAO group, 2 h/day, 10 days, H6M 6 HpM (persistent 28). The permanent model was established based on Zea Longa...
We aimed to determine changes in cognitive function resulting from chronic hypobaric hypoxia through proteomic analysis of hippocampal tissue. screened cognition-related proteins provide ideas and directions that could help prevent treat hypoxia-associated impairment.
Objective To investigate the effect of seasonal and meteorological factors on onset stroke in Qinghai Plateau area. Methods Patients with admitted to Provincial People's Hospital from December 1, 2011 November 30, 2016 were enrolled retrospectively. The data provided by Meteorological Bureau used analyze distribution number cases different seasons area relationship between incidence plateau factors. Results A total 9 412 patients acute ischemic enrolled, aged 15~95 years. There...