A5021200285- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Veterinary Pharmacology and Anesthesia
- Injury Epidemiology and Prevention
- Emergency and Acute Care Studies
- Human-Animal Interaction Studies
- Veterinary Medicine and Surgery
- Anesthesia and Pain Management
- Traumatic Brain Injury Research
- Veterinary Equine Medical Research
- Disaster Response and Management
- Data Mining Algorithms and Applications
- Sentiment Analysis and Opinion Mining
- Pelvic and Acetabular Injuries
- Metabolism and Genetic Disorders
- Veterinary Orthopedics and Neurology
- Hemoglobin structure and function
- Trauma Management and Diagnosis
- Protein Structure and Dynamics
- Spinal Fractures and Fixation Techniques
- Anesthesia and Sedative Agents
- Hip and Femur Fractures
- Biochemical and Molecular Research
- Renal cell carcinoma treatment
Salford Royal NHS Foundation Trust
2016-2025
Bentley University
2017-2023
Royal Society for the Prevention of Cruelty to Animals
2009-2023
Millsaps College
2023
Loyola University Maryland
2023
Wake Forest University
2022
Southmead Hospital
2022
Research Network (United States)
2007-2019
Royal Society
2018-2019
Institute of Population, Health and Development
2019
Book Review| June 01 1976 Biochemical Fluorescence Concepts Concepts. RAYMOND F. CHEN. EDELHOCH HAROLD. Marcel DekkerNew York 1975 pp. 408, $29.50 D. W. YATES Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print 0300-5127 © Society1976 Biochem Soc Trans (1976) 4 (3): 539–540. https://doi.org/10.1042/bst0040539 Views Icon Article contents Figures & tables Video Audio Supplementary...
1. Dihydroxyacetone phosphate exists in neutral aqueous solution at 20 degrees C as a mixture of keto, gem-diol and enolic forms the ratio 55:44:1. 2. The three are freely interconvertible rate constants for these reactions have been determined. 3. Keto-dihydroxyacetone is primary reactive species catalysed by alpha-glycerophosphate dehydrogenase, aldolase triose isomerase. 4. proportion keto form to dihydroxyacetone temperature-dependent. At 37 C, 83% keto-dihydroxyacetone phosphate. 5....
Pre-existing medical conditions (PMCs) have been shown to increase mortality after trauma even adjustment for the effect of chronological aging. It has suggested that there is an interaction between injury severity and physiologic reserve, such diminished reserve will adverse on survival at lower severity, but higher levels much less impact.Records 65,743 patients, admitted trauma, were extracted from database United Kingdom Trauma Network explore impacts age, gender PMCs mortality,...
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing transport, catabolism, and absorption. WAY-252623 (LXR-623) is a highly selective orally bioavailable synthetic modulator LXR, which demonstrated efficacy for reducing lesion progression the murine LDLR(-/-) atherosclerosis model with no associated increase hepatic lipogenesis either this...
1. CoA, acetyl-CoA, l-carnitine and acetyl-l-carnitine when added to rat liver mitochondria equilibrate with approximately two-thirds of the total intramitochondrial water. The mitochondrial space calculated be freely permeable these solutes was identical that obtained for sucrose. 2. Acetyl-CoA is rapidly deacylated by at 0°C, special precautions are required measure its permeation. 3. Rat were separated into fractions correspond inner membrane, outer soluble proteins matrix intermembrane...
Transient kinetic studies of the magnesium ion-dependent ATPase heavy meromyosin have been described using chromophoric analog ATP, 6-mercapto-9-β-ribofuranosylpurine 5′- triphosphate (thioATP) (Trentham et al., 1972). We report here an extension these subfragment 1 and a wider range ATP analogs modified both in adenine moieties.
1. A continuously recording and sensitive fluorimetric assay is described for carnitine palmitoyltransferase. This has been applied to whole or disintegrated mitochondria soluble protein fractions. 2. When rat liver had by ultrasound, the specific activity of palmitoyltransferase was 15-20m-units/mg protein. Only one-fifth this assayable (with added substrates) before mitochondrial disintegration. 3. It concluded that there are two activities in mitochondria, which one (type I) relatively...
Recent evidence suggests that presenting GCS may be higher in older rather than younger patients for an equivalent anatomical severity of traumatic brain injury (TBI). The aim this study was to confirm these observations using a national trauma database and test explanatory hypotheses.The Trauma Audit Research Network interrogated identify all adult cases severe isolated TBI from 1988 2013. Cases were categorised by age into those under 65 years older. Median compared between the groups at...
Research Article| January 01 1966 The Rate-Limiting Step in the Oxidation of Palmitate or Palmitoyl-Coenzyme A by Rat-Liver Mitochondria D. Shepher; Shepher Search for other works this author on: This Site PubMed Google Scholar W. Yates; Yates P. B. Garland Biochem J (1966) 98 (1): 3C–4C. https://doi.org/10.1042/bj0980003C Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn MailTo Cite Get Permissions Citation Shepher,...
An institution's trauma survival rate can be compared with that predicted by TRISS using definitive outcome-based evaluation. This examines W, the difference between actual and rates; Z, statistical significance of this difference; M, a measure similarity injury severity mix to prediction data base. However, it is possible for two institutions same within each band have very different W Z scores whilst retaining similar M score. Clearly unsatisfactory. A new statistic, Wsub s , therefore...
Plasma catecholamine concentrations in cardiac arrest (ventricular fibrillation and asystole) are significantly higher than after myocardial infarction. The levels reached well above those normally required to stimulate activity. Possible reasons for the failure of myocardium respond catecholamines discussed rationale giving more is questioned.
One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). A secondary aim was assess the effects kittens and pregnant animals. Buprenorphine 180 µg/m 2 or butorphanol 6 mg/m with either carprofen 4 mg/kg (groups BUPC BUTC, respectively) meloxicam 0.3...
1. Deca-2,4,6,8-tetraenoic acid is a substrate for both ATP-specific (EC 6.2.1.2 or 3) and GTP-specific 6.2.1.-) acyl-CoA synthetases of rat liver mitochondria. The enzymic synthesis decatetraenoyl-CoA results in new spectral characteristics. difference spectrum the minus free has maximum at 376nm with epsilon(mM) 34. Isosbestic points are 345nm 440nm. 2. acylation CoA by decatetraenoate mitochondrial suspensions can be continuously measured dual-wavelength spectrophotometer. 3. By using...
Background Prediction models for trauma outcome routinely control age but there is uncertainty about the need to comorbidity and whether two interact. This paper describes recent revisions Trauma Audit Research Network (TARN) risk adjustment model designed take account of comorbidities. In addition linkage between TARN Office National Statistics (ONS) database allows patient's be accurately identified up 30 days after injury. Outcome at discharge within was previously used. Methods...