A5088253295- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Genetics, Bioinformatics, and Biomedical Research
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Immune cells in cancer
- Problem and Project Based Learning
Case Western Reserve University
2007-2023
University Hospitals Seidman Cancer Center
2009-2023
University Hospitals of Cleveland
2015-2018
Case Comprehensive Cancer Center
2016-2017
University of Pittsburgh Medical Center
1997-2016
The Neurological Institute
2014
Cleveland Clinic
2014
Cleveland Clinic Lerner College of Medicine
2014
Michigan Center for Translational Pathology
2014
University of Michigan
2014
Object. The role of stereotactic radiosurgery in treating renal cell carcinoma (RCC) metastases to the spine has previously been limited. In this study authors evaluated clinical outcome patients with spinal RCC who underwent single-fraction radiosurgery. Methods. Forty-eight 60 (six cervical, 26 thoracic, 18 lumbar, and 10 sacral) were treated a technique followed for period 14 48 months (median 37 months). All successfully an outpatient setting. tumor volume ranged from 5.5 203 cm 3 (mean...
Abstract BACKGROUND Stereotactic radiosurgery, with or without whole‐brain radiation therapy, has become a valued management choice for patients brain metastases, although their median survival remains limited. In who receive successful extracranial cancer care, have controlled intracranial disease are living longer. The authors evaluated all metastasis in lived ≥ 4 years after radiosurgery to determine clinical and treatment patterns potentially responsible outcome. METHODS Six hundred...
Taxanes have effects on angiogenesis causing difficulties in separating biological of chemotherapy from those due to inhibitors. This randomized phase II trial was designed evaluate the additional biomarker effect when bevacizumab is added docetaxel.Patients with inoperable breast cancer were either 2 cycles preoperative docetaxel (D) 35 mg/m(2) i.v. weekly for 6 weeks, followed by a 2-week break; or 10 mg/kg every other week total 16 weeks (DB). Plasma and serum markers endothelial damage,...
Abstract DNA-based immunization strategies designed to elicit cellular antitumor immunity offer an attractive alternative protein- or peptide-based approaches. In the present study we have evaluated feasibility of DNA vaccination for induction CTL reactivity five different melanoma Ags in vitro. Cultured, monocyte-derived dendritic cells (DC) were transiently transfected with plasmid encoding human MART-1/Melan-A, pMel-17/gp100, tyrosinase, MAGE-1, MAGE-3 by particle bombardment and used...
Background. This study relates our experience in the diagnosis and treatment of a rare clinical entity, non-Hodgkin's primary lymphoma bone. Methods. Seventeen cases patients with bone diagnosed treated at single institution between 1975 1992 are reviewed. Ten received combined-modality therapy, consisting an anthracycline-containing combination chemotherapy (CT) regimen, followed by adjuvant radiotherapy (RT) to site disease. Five were CT alone; one patient RT was after emergency for spinal...
Abstract Purpose: BAY 50-4798 is an analogue of interleukin-2 that selectively activates T cells over natural killer cells. This phase I study was designed to determine the maximum tolerated dose (MTD) and safety 50-4798, screen for tumor response, assess pharmacokinetics. Experimental Design: Forty-five patients with metastatic melanoma or renal cancer were enrolled, 31 on escalating doses MTD, 20 cell carcinoma treated at MTD detect antitumor activity. delivered i.v. every 8 h, days 1 5 15...
The methods used to analyze and interpret clinical trials of chemotherapy may have a major impact on the conclusions that are drawn in papers reporting them. To illustrate this problem, we constructed hypothetical trial which patients with metastatic cancer were treated chemotherapy. following two articles provide reports trial, analyzed by would as being low high quality, respectively. In present report, describe briefly methodological differences led opposite based single set data. errors...
The proteasome inhibitor bortezomib enhances the effect of selective estrogen receptor (ER) downregulator (SERD) fulvestrant by causing accumulation cytoplasmic ER aggregates in preclinical models. purpose this trial was to determine whether enhanced effectiveness fulvestrant. One hundred eighteen postmenopausal women with ER-positive metastatic breast cancer resistant aromatase inhibitors (AIs) were randomized alone (Arm A-500 mg intramuscular (i.m.) day -14, 1, 15 cycle and 1 additional...
For patients with progressive breast cancer brain metastasis (BCBM) after whole radiotherapy (WBRT), few options exist. Patupilone is an epothilone that crosses the blood–brain barrier. We hypothesized patupilone would produce a 35% 3-month CNS progression-free survival in women BCBM WBRT. This multicenter phase II trial included 2 cohorts. Group A B was exploratory cohort of either leptomeningeal metastases or untreated metastases. The primary goal to observe A. sample size 45 for and 10 B....
Abstract Purpose: A single arm, phase II trial of carboplatin, nab-paclitaxel, and pembrolizumab (CNP) in metastatic triple-negative breast cancer (mTNBC) was designed to evaluate overall response rate (ORR), progression-free survival (PFS), duration (DOR), safety/tolerability, (OS), identify pathologic transcriptomic correlates therapy. Patients Methods: with ≤2 prior therapies for disease were treated CNP regardless tumor programmed cell death-ligand 1 status. Core tissue biopsies obtained...
We have utilized a lambda Charon 4A human genomic library to isolate recombinant clones harboring highly conserved c-src locus containing nucleotide sequences homologous the transforming gene of Rous sarcoma virus (v-src). Four overlapping spanning 24 kilobases cellular DNA were analyzed by restriction endonuclease mapping. Human entire v-src region are present in 20-kilobase that contains 11 exons as determined mapping studies utilizing hybridization labeled probes representing various...
Dendritic cells (DC) are potent antigen-presenting that important for the priming of antitumor cytotoxic T cells. Recent reports suggest DC may also have direct effector functions against selected tumor-cell lines by mechanisms dependent on dendritic cell-tumor cell contact in vitro. The authors report ex vivo-generated murine induce apoptosis a panel syngeneic and allogeneic tumors. Apoptosis MCA205 fibrosarcoma line C57BL/6-derived was not mediated Fas/FasL interactions and, contrast to...
Abstract BACKGROUND: Abnormalities of the PI3kinase/AKT/mTOR signaling network are common in breast cancer (BC) and associated with endocrine resistance. Everolimus, an mTOR-inhibitor increased PFS when combined therapy (ET) metastatic setting is thought to revert S1207 a phase III randomized, placebo-controlled trial evaluating role everolimus combination ET adjuvant among patients high-risk hormone receptor-positive, HER2-negative BC (NCT01674140). METHODS: Eligible were >18 years...
It has been more than 100 years since Dr. William B. Coley reported the regression of tumors in some patients who had injected with bacterial extracts [1]. Since this early exercise cancer vaccination, clinicians and scientists have attempted to harness immune system mediate rejection vivo. Because many important recent discoveries immunology tumor cell biology, we now exciting opportunity explore therapeutic potentials novel vaccines.
The Ig heavy chain class switch usually occurs by breaking and rejoining DNA in the (S) regions, which consist of tandemly repeated sequences 5' constant region exons. Various studies have suggested that S can also recombine with non-S sequences. To measure frequency such recombination events, hybridoma cell line igm692, a deletion mutant lacks C mu 1 2 exons 3' end region, was transfected fragment bearing 1-2 exons, but no DNA. Insertion this into residual VDJ-C intron igm692 restore...
Abstract Background: Physicians often are called on to participate in and interpret clinical trials, but their training this area may not provide them with the inquiry skills that needed. Simulations have potential be a promising tool for helping medical students learn involved trial design. However, simulations complex require additional scaffolding support learning. Description: The goal of study was teach aspects cancer design through scaffolded use simulation, Oncology Thinking Cap....
We recently reported that transfected DNA inserts into the VDJ-Cmu intron much more frequently than average DNA, and insertion within this occurs preferentially switch region. To gain information about mechanisms involved in insertion, we sequenced 5' 3' junctions of typical transformants. Although junction sequences did not indicate a preferred motif region, our results suggest joining chromosomal DNAs is facilitated by short regions identity. Our analysis insertions non-switch part...