A5087785094- Biomedical and Chemical Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Dysphagia Assessment and Management
- Abdominal Trauma and Injuries
- Pain Management and Placebo Effect
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Appendicitis Diagnosis and Management
- Cleft Lip and Palate Research
- Neuroendocrine regulation and behavior
- Craniofacial Disorders and Treatments
- Anesthesia and Pain Management
- Amoebic Infections and Treatments
- Esophageal and GI Pathology
- Spine and Intervertebral Disc Pathology
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
- Tracheal and airway disorders
University Hospital Bonn
2023
University of Bonn
2023
Merck (Germany)
2023
Universitätsklinikum Erlangen
2009
Heidelberg University
1987
Introduction: Cleft lip ± cleft palate (CL/P) is one of the most common birth defects. Although research has identified multiple genetic risk loci for different types CL/P (i.e., syndromic or non-syndromic forms), determining respective causal genes and understanding relevant functional networks remain challenging. The recent introduction single-cell RNA sequencing (scRNA-seq) provided novel opportunities to study gene expression patterns at cellular resolution. aims our were to: (i)...
A crucial design feature for the therapeutic success of antibody-drug conjugates (ADCs) is linker that connects antibody with drug. Linkers must be stable in circulation and efficiently release drug inside target cell, thereby having a fundamental impact on ADC pharmacokinetics efficacy. The variety enzymatically cleavable linkers applied ADCs limited, some are believed to associated unwanted side effects due expression cleavage-mediating enzymes nonmalignant cells. Based bioinformatic...
Bei 60 Patientinnen, die sich einer Abrasio uteri in Thiopental-induzierter Maskennarkose mit Enfluran und N2O/O2 im Verhältnis 2:1 unterziehen mußten, wurden Wirkungen oralen Prämedikation zwei Stunden vor Anästhesiebeginn 30 mg oralem Morphin (MST 30) (n = 21), 1mg Lormetazepam (Noctamid) 19) Plazebo 20) auf psychologische (Angst, Depression Asthenie), physiologische (Blutdruck, Herz- Atemfrequenz) Schmerzparameter (visuelle Analogskala, Narkosemittel- Analgetika-Verbrauch) Rahmen...