A5046395462- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Nutrition and Health in Aging
- Plant biochemistry and biosynthesis
- Cardiovascular Function and Risk Factors
- Surgical Simulation and Training
- Cancer and Skin Lesions
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Testicular diseases and treatments
- Cancer Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Esophageal Cancer Research and Treatment
- Pharmacogenetics and Drug Metabolism
- Cardiac tumors and thrombi
- Microbial Metabolic Engineering and Bioproduction
- Heart Failure Treatment and Management
- Appendicitis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Anatomy and Medical Technology
Paracelsus Medical University
2016-2024
Merck (Germany)
2008-2024
University of Salzburg
2022-2024
Target (Germany)
2019-2024
Krankenhaus Oberndorf
2024
Leipzig Heart Institute
2023
Humboldt-Universität zu Berlin
2023
Salzburger Landeskliniken
2016-2022
Paracelsus Medizinische Privatuniversität
2018-2019
Merck Serono (Italy)
2014
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it unclear whether this will impact on the clinical utility inhibitors. We discovered two series potent chemical probes with high selectivity for CDK8/19. Despite pharmacodynamic evidence robust on-target activity, compounds exhibited modest, though significant, efficacy against human tumor lines and patient-derived xenografts....
Site-specific bioconjugation technologies are frequently employed to generate homogeneous antibody–drug conjugates (ADCs) and generally considered superior stochastic approaches like lysine coupling. However, most of the developed so far require undesired manipulation antibody sequence or its glycan structures. Herein, we report successful engineering microbial transglutaminase enabling efficient, site-specific conjugation drug-linker constructs position HC-Q295 native, fully glycosylated...
Abstract Three-dimensional (3D) printing of vascular structures is special interest for procedure simulations in Interventional Radiology, but remains due to the complexity system and lack biological tissue mimicking 3D materials a technical challenge. In this study, feasibility, accuracy, usability recently introduced silicone-like resin were evaluated endovascular technically compared commonly used standard clear resin. Fifty-four models based on twenty-seven consecutive embolization cases...
The bifunctional methylerythritol 4-phosphate cytidylyltransferase 2,4-cyclodiphosphate synthase (IspDF) is unusual in that it catalyzes nonconsecutive reactions the 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway of isoprenoid precursor biosynthesis. crystal structure IspDF from bacterial pathogen Campylobacter jejuni reveals an elongated hexamer with D3 symmetry compatible dimeric 2C-methyl-D-erythritol-4-phosphate and trimeric 2C-methyl-D-erythritol-2,4-cyclodiphosphate monofunctional...
Fragment crystallizable (Fc) antigen binding fragments (Fcabs) represent a novel antibody format comprising homodimeric Fc region with an engineered site. In contrast to their full-length offspring, Fcabs combine Fc-domain-mediated and functions at only one-third of the size. Their reduced size is accompanied by elevated tissue penetration capabilities, which attractive feature for treatment solid tumors. present study, we explored first time as scaffold antibody-drug conjugates (ADCs). As...
306Three-dimensional (3D)-printed vascular models for cardiovascular surgery planning and endovascular procedure simulations often lack realistic biological tissues mimicking material properties, including flexibility or transparency, both. Transparent silicone silicone-like were not available end-user 3D printers had to be fabricated using complex cost-intensive workarounds. This limitation has now been overcome by novel liquid resins with tissue properties. These new materials enable...
Current guidelines of the National Comprehensive Cancer Network and European Society Medical Oncology recommend regorafenib or trifluridine/tipiracil (TAS-102) for third-line therapy metastatic colorectal cancer (mCRC). We evaluated impact TAS-102 treatment on skeletal muscle dynamics sarcopenia.This retrospective analysis was based unselected, consecutive mCRC patients treated with and/or during third later line at our tertiary-care center in Salzburg, Austria. The index (SMI, cm2/m2)...
Objective. To assess the relationship between blood pressure changes following infusion of antidotal doses hydroxocobalamin and plasma concentrations total free cobalamins-(III). Methods. Independent groups healthy volunteers received single intravenous 2.5, 5, 7.5, or 10 g over 7.5 to 30 minutes. Results. In pharmacokinetic population (n = 41), caused short-lived mean increases. Blood increased shortly after initiation returned nearly baseline by 4 hours post-infusion. The time course...
A crucial design feature for the therapeutic success of antibody-drug conjugates (ADCs) is linker that connects antibody with drug. Linkers must be stable in circulation and efficiently release drug inside target cell, thereby having a fundamental impact on ADC pharmacokinetics efficacy. The variety enzymatically cleavable linkers applied ADCs limited, some are believed to associated unwanted side effects due expression cleavage-mediating enzymes nonmalignant cells. Based bioinformatic...
Abstract Background Transthoracic echocardiography (TTE) offers a measurement method for the determination of pulmonary hypertension (PH) in patients with severe aortic valve stenosis (AS) maximal tricuspid regurgitation velocity (TRVmax) and systolic artery pressure (sPAP). Radiological parameters noninvasive detection PH, most importantly computed tomography (CT) based PA/AA-ratio = ratio diameter (PA) ascending aorta (AA), are also included latest ESC guidelines. The aim present study was...
Recombinant 1-deoxy-D-xylulose 5-phosphate synthase of Bacillus subtilis was used for the preparation isotope-labeled using glucose and/or pyruvate as starting materials. The simple one-pot methods described afford almost every conceivable isotopomer carrying (13)C or (14)C from commercially available precursors with an overall yield around 50%.
Endovascular embolization techniques are nowadays well established in the management of acute arterial bleedings. However, education and training next generation interventionalists still based on traditional apprenticeship model, where trainee learns practices directly at patient, which potentially affects patient's safety. The objective this study was to design develop a standardized endovascular simulation concept for bleeding embolizations, real-life cases.An adaptable cost-effective...
Perioperative chemotherapy with FLOT constitutes a standard of care approach for locally advanced, resectable gastric or gastro-esophageal junction (GEJ) cancer. We aimed at investigating anthropometric, CT-based and FDG-PET-based body composition parameters dynamics during this multidisciplinary the impact on clinical outcomes.This retrospective, single-center study was based medical records (FDG-PET)-CT images among gastric/GEJ cancer patients undergoing perioperative chemotherapy.Between...
(1) Background: Currently, echocardiography is the primary non-invasive diagnostic method used to screen patients with severe aortic valve stenosis (AS) for pulmonary hypertension (PH) by estimating systolic artery pressure (sPAP). Other radiological methods have been a focus of research in past couple years, as it was shown that determining (PA) diameter, prognostic statements concerning overall mortality could be made these patients. This study compared established and novel cardiovascular...
Akuter Unterbauchschmerz bei Frauen kann u. a. gynäkologische, gastrointestinale oder urologische Ursachen haben. Extrauteringravidität (EUG), "pelvic inflammatory disease" (PID) und rupturierte Ovarialzysten sind die häufigsten gynäkologischen für akuten Unterbauchschmerz. Die korrekte Diagnosestellung ist klinisch herausfordernd. genaue Anamnese, klinische Untersuchung erhobene Laborwerte einerseits sowie Alter Schwangerschaftsstatus der Patientin andererseits schränken...
To retrospectively evaluate whether prone CT scanning is superior to supine for correct localization of distal urinary calculi in patients with acute flank pain. Consecutively performed unenhanced scans pain were analyzed 150 and another position. Images reviewed by two radiologists on consensus. Findings both groups compared using two-sided Fisher Exact tests Wilcoxon–Mann–Whitney test. Urinary found 67% each group. In the group, there 16 cases, which location stone was equivocal being...
Emerging applications of photochromic compounds demand new molecular designs that can be inspired by some long-known yet currently forgotten classes photoswitches. In the present review, we would like to remind community about Peri-AryloxyQuinones (PAQs) and their unique photoswitching behavior originally discovered Gerasimenko more than 50 years ago. At heart this phenomenon is light-induced migration an aromatic moiety (arylotropy) in peri-aryloxy-substituted quinones resulting...
Background: Echocardiography has long been established as the primary noninvasive method for diagnosing pulmonary hypertension (PH) prior to transcatheter aortic valve replacement (TAVR) in patients with severe stenosis (AS). In recent years, radiological methods PH have investigated. Measurements such computed tomography angiography (CTA)-derived artery (PA) diameter and PA diameter/body surface area (PA/BSA) shown promising results regarding their diagnostic strength. However, it yet be...