A5102966027- Metalloenzymes and iron-sulfur proteins
- RNA modifications and cancer
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Pain Management and Opioid Use
- RNA Research and Splicing
- Psychiatric care and mental health services
- Actinomycetales infections and treatment
- Obsessive-Compulsive Spectrum Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vascular Anomalies and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Behavioral Health and Interventions
- Restraint-Related Deaths
- Opioid Use Disorder Treatment
- Intensive Care Unit Cognitive Disorders
- Mycorrhizal Fungi and Plant Interactions
- Immune Cell Function and Interaction
- Medication Adherence and Compliance
- Infectious Diseases and Mycology
- Blood Pressure and Hypertension Studies
- Social Media in Health Education
- Mental Health via Writing
NIHR Imperial Biomedical Research Centre
2023-2024
National Institute for Health Research
2023-2024
Imperial College Healthcare NHS Trust
2022-2024
University of Chicago
2023
Medical Decision Modeling (United States)
2021
Baidu (China)
2018
National Institutes of Health
2006
Despite whole-genome sequencing (WGS), many cases of single-gene disorders remain unsolved, impeding diagnosis and preventative care for people whose disease-causing variants escape detection. Since early WGS data analytic steps prioritize protein-coding sequences, to simultaneously in non-coding regions rich transcribed critical regulatory we developed GROFFFY, an tool that integrates coordinates with experimental evidence functionality. Applied from solved unsolved hereditary hemorrhagic...
Baricitinib–remdesivir (BARI-REM) combination is superior to remdesivir (REM) in reducing recovery time and accelerating clinical improvement among hospitalized patients with coronavirus disease 2019 (COVID-19), specifically those receiving high-flow oxygen/noninvasive ventilation. Here we assessed the cost-effectiveness of BARI-REM versus REM COVID-19 USA. A three-state model was developed addressing costs patient utility associated hospitalization, immediate post hospital care, subsequent...
Abstract Human peripheral blood mononuclear cells (PBMCs) are used to examine biological processes and disease, when basal variability in cellular activation splicing is described unexplained. Using isolation systems that maintained buffy coat (PBMCs, platelets) their own plasma, poly-A enriched RNA-sequencing (RNASeq) detected 42,720 Ensembl gene IDs, including >95% of the top 100 Genotype Tissue Expression Project (GTEx)-expressed genes lung, colon, heart, skeletal muscle liver, 10/17...
Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia that commonly results in bleeding but with frequent indications for therapeutic anticoagulation. Our aims were to advance the understanding of drug-specific intolerance and evaluate if there was an indication pharmacogenomic testing. Genes encoding proteins involved absorption, distribution, metabolism, excretion warfarin, heparin, direct oral anticoagulants (DOACs) apixaban, rivaroxaban, edoxaban, dabigatran identified...
Abstract Despite whole genome sequencing (WGS), why do many single gene disorder cases remain unsolved, impeding diagnosis and preventative care for people whose disease-causing variants escape detection? Early WGS data analytic steps prioritize protein-coding sequences. To simultaneously prioritise in non-coding regions rich transcribed critical regulatory sequences, we developed GROFFFY, an tool which integrates coordinates with experimental evidence of functionality. Applied to from...
Mycetoma is a neglected tropical disease with an unknown global burden. Although considered endemic to South-east Asia, it has not previously been reported from Timor-Lest. We describe two cases in Timor-Leste, highlighting the challenges surrounding microbiological diagnosis and management shared by many low middle-income countries. As characteristically described, both patients lived rurally presented late marked soft tissue involvement multiple draining sinuses following prolonged period...
<h3>To the Editor.</h3> —In my work as a medical director of methadone clinic I see how city streets are flooded with pharmaceutical opiates. Addicts use them in times when heroin is scarce and may begin their addiction taking pharmaceuticals for one reason or another. Physicians, it goes without saying, easily inveigled. It gross oversimplification physicians to think only Dr Hill<sup>1</sup>would advise, patients demand adequate pain treatment any all types pain. extremely difficult decide...