A5046598216- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Intensive Care Unit Cognitive Disorders
- MRI in cancer diagnosis
- Infective Endocarditis Diagnosis and Management
- Geriatric Care and Nursing Homes
- Kawasaki Disease and Coronary Complications
- Biochemical and Structural Characterization
- Surgical site infection prevention
- Cutaneous lymphoproliferative disorders research
- Primary Care and Health Outcomes
- SARS-CoV-2 detection and testing
- Infectious Diseases and Mycology
- Actinomycetales infections and treatment
- Social Media in Health Education
- Coronary Artery Anomalies
- Vasculitis and related conditions
- Lung Cancer Treatments and Mutations
- Healthcare Policy and Management
University of Sheffield
2022-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2013-2023
National Health and Medical Research Council
2021
Intensive Care National Audit & Research Centre
2021
University of Dundee
2021
Medical Research Council
2021
University of Iowa Hospitals and Clinics
2020-2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
To evaluate the diagnostic performance of multiple machine learning classifier models derived from first-order histogram texture parameters extracted T1-weighted contrast-enhanced images in differentiating glioblastoma and primary central nervous system lymphoma.Retrospective study with 97 46 lymphoma patients. Thirty-six different combinations feature selection techniques were evaluated. Five-fold nested cross-validation was performed. Model assessed for whole tumour largest single slice...
Magnetic resonance texture analysis (MRTA) is a relatively new technique that can be valuable addition to clinical and imaging parameters in predicting prognosis. In the present study, we investigated efficacy of MRTA for glioblastoma survival using T1 contrast-enhanced (CE) images analysis.We evaluated diagnostic performance multiple machine learning models based on first-order histogram statistical derived from T1-weighted CE stratification multiforme (GBM). Retrospective evaluation 85...
Prevention of cardiac surgical site infection has largely focused on reducing due to Staphylococcus aureus, although other bacteria also play an important role in this complication.To assess the impact evolving control programme incidence sternal wound (SWI), and changing non-staphylococcal infections.A retrospective cohort study all patients who underwent primary sternotomy at a single UK centre between September 2010 May 2018 was undertaken. Data were collated from 2 years preceding...
Background: Cognitive impairment is common amongst acute geriatric hospital admissions but detection often poor and this associated with worse outcomes. The four-question abbreviated mental test (AMT4) has previously been promoted nationally in the setting as a succinct assessment tool. However, recent national dementia Commissioning for Quality Innovation (CQUIN) goal recommends single screening question followed by tenquestion (AMT10). We aimed to evaluate negative predictive value of AMT4...
Methicillin-resistant
Rabbit pox virus (RPV) produced cytopathic effect (CPE) in five types of cells grown tissue cultures. The CPE on CV-1 was characterized by cell fusion and lysis. line is a useful sensitive culture for measuring concentrations RPV blood tissues infected rabbits. Viremia detected between the 2nd 4th days after parenteral infection. By 6th 7th days, concentration various ranged from 10 5-3 to 8-5 TCID 50 /g. Cross-reactivity demonstrated fluorescent-antibody technique rabbit pox, vaccinia,...
A man in his 20s attended the emergency department with three days of fever, headache, reduced appetite and a sore throat. COVID-19 point-of-care test was negative. Blood cultures grew gram-negative coccobacillus, Neisseria elongata . Following an episode confusion, MRI head revealed septic emboli. Prolapse mitral valve regurgitation noted on echocardiography. Infection found to have originated from multiple dental caries treatment required combination extraction, prolonged antibiotic...
Mycetoma is a neglected tropical disease with an unknown global burden. Although considered endemic to South-east Asia, it has not previously been reported from Timor-Lest. We describe two cases in Timor-Leste, highlighting the challenges surrounding microbiological diagnosis and management shared by many low middle-income countries. As characteristically described, both patients lived rurally presented late marked soft tissue involvement multiple draining sinuses following prolonged period...
Purpose: To evaluate the impact of repeat head computed tomography (CT) during (1) interfacility transfer and (2) inpatient and/or outpatient follow-up on management, cost-effectiveness, radiation dose in neurologically stable patients with mild traumatic subarachnoid hemorrhage (tSAH). Material Methods: This is a single-center retrospective study evaluating tSAH presenting between January 2017 July 2019. A total 101 140 met eligibility criteria for first second subgroups, respectively....
Henoch-Schönlein purpura is a small vessel vasculitis with multi-system manifestations that commonly affects children. We describe case of new onset in previously healthy 42-year-old female who required an emergency laparotomy for bowel perforation.
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Ibrutinib is a small molecule inhibitor that targets Bruton’s tyrosine kinase (BTK), crucial enzyme the B cell receptor (BCR) pathway responsible for growth and differentiation of cells by activating multiple transcription factors it has become promising treatment option various cancers, including chronic lymphocytic leukemia (CLL), mantle lymphoma, Waldenström’s macroglobulinemia. However, use BTK inhibitors...