A5045100337- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Syphilis Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
- Platelet Disorders and Treatments
- Dermatological and COVID-19 studies
- COVID-19 Clinical Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Blood groups and transfusion
- Bone Tumor Diagnosis and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Complement system in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Global Health and Epidemiology
- Advanced X-ray and CT Imaging
- Brain Metastases and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pancreatic and Hepatic Oncology Research
University of Kansas Medical Center
2024
University of Pittsburgh Medical Center
2022-2023
UPMC Health System
2023
University of Iowa Hospitals and Clinics
2019-2022
University of Washington
2021
American Society for Clinical Pathology
2021
Cornell University
2018
Weill Cornell Medicine
2018
University of Iowa
2018
All India Institute of Medical Sciences
1964-2018
SUMMARY 1. The residual protein content per unit DNA of the tissue rises markedly in occipital cortex, cerebral tectum and hippocampus developing rabbits days following opening eyes. change is much less marked cerebellar cortex during this period. 2. Prior blinding animals diminishes significantly rise proteins cortex. effect on expected other areas not significant. 3. Exposure adult to light stimulates incorporation dl ‐[1‐ 14 C]‐ valine [U‐ C]glucose into as compared kept dark room.
Distant metastases, although rare, account for maximum disease-related mortality in differentiated thyroid cancer (DTC). Lungs and bones are the most frequent sites of metastases. We sought to identify prognostic factors adult DTC patients presenting with pulmonary metastases at initial diagnosis.Retrospective cohort study.From medical records 4370 patients, 200 aged more than 21 years who were identified have time diagnosis included analysis.The lungs alone 133 (67%) additional remaining 67...
The role of platelet transfusions in management Immune Thrombocytopenia (ITP) remains controversial. Current guidelines recommend that ITP be reserved for catastrophic hemorrhage or invasive surgical procedures. This study assesses the nationwide transfusion practices hospitalized children and adults with ITP.We studied hospitalizations as primary admitting diagnosis from 2010-2014 National Inpatient Sample (NIS), largest all-payer inpatient database. Univariate multivariable logistic...
This study was aimed at identifying the prognostic factors predicting remission in pediatric differentiated thyroid cancer (DTC) patients presenting with pulmonary metastases. Little is known about reference to DTC metastases.Fifty-three aged ≤21 years were diagnosed metastases initial presentation. The demographic and disease characteristics compared between who achieved those did not.During median follow-up of 72 months, 38 became free, 14 had biochemically and/or structurally persistent...
The mute question is whether patients with DTC of intermediate risk recurrence, second most common presentation, who were surgically ablated in the first place, ever needed adjuvant RAI therapy? This study exclusively evaluated long-term outcome intermediate-risk DTC.Two-arm retrospective cohort conducted between years 1991 and 2012.Institutional practice.Intermediate-risk patients, pathologically proven T1/2 N1 M0, T3 with/without M0 disease, a minimum follow-up 12 months, included. Of 254...
Abstract Objectives Two new classifications of myeloid neoplasms have recently been published: the International Consensus Classification (ICC) and 5th edition World Health Organization classification (WHO5). We sought to examine real-world impact dueling on patient diagnoses. Methods Our institutional pathology database was searched, 237 specimens with a diagnosis neoplasia were randomly selected. For each case, based WHO5 ICC assigned. The diagnoses compared determine their degree...
Corrosive acid ingestion is a rare but serious health hazard with fatal complications. Cases of suicidal and accidental have been documented in the scientific literature. Accidental poisoning due to mistaken identity bottle containing sulphuric matter grave concern especially household set-up. We hereby report case an adult, who unsuspectingly swallowed about 50 ml ‘toilet-cleaner’ at his residence. The was recently purchased from local vendor placed water bottles kitchen. autopsy...
The aim of this work was to evaluate the influence solid organ malignancies on in-hospital outcomes and recurrent strokes among patients hospitalized with acute ischemic stroke (AIS).Adult hospitalizations a primary diagnosis AIS were identified from Nationwide Readmissions Database 2016 2018. Logistic regression used compare differences in use interventions clinical without malignancy. Survival analysis risk readmission due after discharge.There 1,385,840 (mean ± SD age 70.4 14.0 years,...
Summary Thyroid cancer is treated by thyroidectomy followed radioiodine ablation of the residual active tissue in thyroid bed. Completeness can be assessed from neck images whole-body 131I scans visual estimation or quantitative analysis. By assessment, considered complete if there no uptake empirically too small. quantification, < 1%. Further therapy necessary only exceeds 1% administered dose. Both assessment and quantification bed were applied to 46 after diagnostic therapeutic doses had...
Abstract Low‐risk ( LR ) differentiated thyroid cancer DTC patients should be ablated or not, albeit, with small dose of radioiodine is highly controversial. We hypothesized that those who were surgically need no remnant ablation RRA ). This study aims to evaluate the long‐term outcome in these two groups patients. Retrospective cohort conducted from January 1991 December 2012. Based on extent surgical resection and histopathology, classified as Gr‐1: 169 patients, ablated; Gr‐2: 153 had...
Objective of the study Therapeutic options for pediatric Graves’ disease (PGD) include antithyroid drug therapy (ATD) as first line and radioiodine (I-131) second treatment. To date, controversies persist regarding true effect prior ATD in outcome I-131 PGD. This evaluated carbimazole treatment on Methods is a retrospective covering years 1995–2012, with median follow-up 75 months. Records 114 children (84 girls 30 boys, age range: 5–20 years, mean 24-h uptake, 58%) who had clinically...
This study describes an unusual case of multiple myeloma that progressed to anaplastic in the pleural fluid. The Wright-stained cytospin fluid showed a predominant population mononuclear plasma cells with pleomorphic nuclei, characterized by both small and large which is typical myeloma. However, there were also more binuclear nuclei. Morphometric analysis mean nuclear length was 1.9-fold 2.3-fold higher nuclei compared for cells, respectively (p<0.001). patient received B cell maturation...
We evaluated and compared the peripheral blood findings in patients with acute COVID-19 vs other viral respiratory infections.We retrospectively reviewed counts smear morphology a positive panel (VRP) or SARS-CoV-2 test.A total of 97 samples (COVID-19 infection, 53; VRP positive, 44) from 50 (mean [SD] age, 45.8 [20.8] years; females 52%) were reviewed. There no statistically significant differences demographic characteristics between 2 groups. The most common abnormalities anemia,...
Therapeutic plasma exchange (TPE) is often impacted by difficulties in obtaining an adequate and safe vascular access. This study evaluated the rates, predictive factors, clinical outcomes associated with central venous catheter (CVC) use during inpatient TPE procedures.The Nationwide Readmissions Database, 2016 to 2017 was used identify hospitalizations without CVC insertion.During period, there were 35 429 (pediatric 6.1%, mean ± standard deviation (SD) age 50.9 20.0 years, female 52.7%)....
We sought to investigate the clinical utility of flow cytometry (FC) and fluorescence in situ hybridization (FISH) workup myeloma.We retrospectively reviewed reports bone marrow biopsies received for myeloma evaluation between October 2015 January 2019.A total 1,708 biopsy specimens from 469 patients (mean age, 64.5 years [SD, 9.3]; female, 41.4%) were reviewed. Both FC FISH had comparable detection rates at time initial diagnosis (97.6% vs 98.8%) follow-up cases (28.6% 28.2%). results...
<b>Background:</b> Hepatocyte Paraffin 1 (Hep Par 1) was being extensively used to recognize the hepatocellular carcinomas, until recognition of its expression in tumors without differentiation. <b>Aims and Objectives:</b> The aim this study analyze if Hep stain can serve as a specific marker small intestinal (SI) adenocarcinomas, versus other gastrointestinal tract (GIT) primary tumors. <b>Materials Methods:</b> In retrospective cross-sectional study, normal GIT mucosa (<i>n</i> - 60),...
Immunoassays are widely used as screening tests for HIV and syphilis in clinical, public health, research settings. For syphilis, immunoassays 'reverse algorithms' that start with treponemal such IgG or total antibodies the initial screen. Many use signal-to-cutoff (S/CO) values determining positivity, a cutoff value 1.0 differentiating positive from negative. Published literature indicates S/CO often correlates likelihood of subsequent confirmation infections, low barely exceeding more...