A5090850409- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Porphyrin Metabolism and Disorders
- Neonatal Health and Biochemistry
- Radioactive element chemistry and processing
- Chemical Reactions and Isotopes
- Crystal Structures and Properties
- Virus-based gene therapy research
- Chemical Reaction Mechanisms
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Analysis
- Solid-state spectroscopy and crystallography
- Inorganic and Organometallic Chemistry
- Chemical synthesis and alkaloids
- Biochemical and Molecular Research
- Synthesis and Biological Activity
- Chronic Lymphocytic Leukemia Research
Universitat de Barcelona
1997-2024
Université de Rennes
1989
A Diels–Alder reaction leading to 4-nitrophenylcyclohexanones followed by a newly developed base-mediated reductive cyclization of the resulting ketone tethered nitrobenzene moiety gives access hexahydro-2,6-methano-1-benzazocine ring system present in several biologically interesting natural products such as aspernomine. The scope was explored with eight substituted nitrobenzenes, obtaining yields up 87%. highest cytotoxicity observed benzazocine 4h, bearing an enone moiety, which active...
One of the most significant limitations that therapeutic oligonucleotides present is development specific and efficient delivery vectors for internalization nucleic acids into cells. Therefore, there a need new transfection agents ensure proper mammalian cells.We describe synthesis 1,3,5-tris[(4-oelyl-1-pyridinio)methyl]benzene tribromide (TROPY) proceeded to validation its binding capacity toward oligonucleotides, DNA cells, effect on cell viability, apoptosis, capability transfect plasmid...
Transfection agents play a crucial role in facilitating the uptake of nucleic acids into eukaryotic cells offering potential therapeutic solutions for genetic disorders. However, progress this field needs development improved systems that guarantee efficient transfection. Here, we describe synthesis set chemical delivery (TRIFAPYs) containing alkyl chains different lengths based on 1,3,5-tris[(4-alkyloxy-1pyridinio)methyl]benzene tribromide structure. Their properties oligonucleotides were...
Abstract By reaction of the dicesium salts long chain dicarboxylic acids (C atoms > 9) with methylene iodide corresponding diesters were prepared. These acylals, by reduction NaBH4 in THF, give ω-hydroxy acids.
Abstract La(OH) 2 NO 3 crystallizes in space group P21/m with Z=2 and ·H O C2/m Z=4.