A5036759352- Insect Resistance and Genetics
- Insect behavior and control techniques
- Insect and Pesticide Research
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- Erythrocyte Function and Pathophysiology
- Insect-Plant Interactions and Control
- Genomics and Chromatin Dynamics
- Heat shock proteins research
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Fungal Plant Pathogen Control
- Advanced biosensing and bioanalysis techniques
Hunan University
2023-2024
Southwest University
2020-2022
Abstract BACKGROUND The oriental fruit fly, Bactrocera dorsalis (Hendel), is a widespread agricultural pest that has evolved resistance to many commonly used insecticides including malathion. Glutathione S ‐transferases (GSTs) are multifunctional enzymes metabolize directly or indirectly. specific mechanism by GSTs confer malathion in B. unclear. RESULTS BdGSTd9 was identified from and expressed at twice the level malathion‐resistant strain (MR) than susceptible (MS). By using RNAi of ,...
Abstract BACKGROUND Long non‐coding RNAs (lncRNAs) play important roles in the regulation of biological processes and have been identified many species including insects. However, association between lncRNAs pesticide resistance insect such as Bactrocera dorsalis is unknown. RESULTS RNA‐seq was performed on malathion resistant (MR1) susceptible (MS) strains B. a total 6171 transcripts were identified. These included 3728 lincRNAs, 653 antisense lncRNAs, 1402 intronic 388 sense lncRNAs. A 40...
Cell fate is precisely modulated by complex but well-tuned molecular signaling networks, whose spatial and temporal dysregulation commonly leads to hazardous diseases. Biomolecular condensates (BCs), as a newly emerging type of biophysical assemblies, decipher the codes bridging behaviors, axes, clinical prognosis. Particularly, physical traits BCs play an important role; however, panoramic view from this perspective toward practices remains lacking. In review, we describe most typical five...
Solid stress, originating from rigid and elastic components of extracellular matrix cells, is a typical physical hallmark tumors. Mounting evidence indicates that elevated solid stress drives metastasis affects prognosis. However, the molecular mechanism how cancer cells sense thereby exacerbating malignancy, remains elusive. In this study, our clinical data suggest in metastatic tumors highly associated with expression cytoskeleton-associated protein 4 (CKAP4). Intriguingly, CKAP4, as...
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate the fast action of in synaptic cholinergic transmissions. Insect nAChRs target several classes insecticides. Here, full-length cDNA encoding a nAChR beta1 subunit (Bdorβ1) was identified and characterized from destructive pest, Bactrocera dorsalis. The amino acid sequence Bdorβ1 shows high identities to other insect β1 subunits. Double injection dsBdorβ1 reduced expression turn significantly decreased...
DNA aptamers are single-stranded oligonucleotide sequences that bind to specific targets with high affinity. Currently, can be produced only by in vitro synthesis. It is difficult for have a sustained impact on intracellular protein activity, which limits their clinical application. In this study, we developed aptamer expression system generate functional activity mammalian cells mimicking retroviruses. Using system, targeting Ras (Ra1) and membrane-bound CD71 (XQ2) were successfully...