A5102151062- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Antibiotics Pharmacokinetics and Efficacy
- Immune Cell Function and Interaction
- Cardiac Imaging and Diagnostics
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- T-cell and B-cell Immunology
- Coronary Interventions and Diagnostics
- Pharmaceutical studies and practices
- Platelet Disorders and Treatments
- Macrophage Migration Inhibitory Factor
- Pancreatitis Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
- Cell death mechanisms and regulation
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Diabetes Management and Education
- Liver physiology and pathology
- Fibroblast Growth Factor Research
- Heat shock proteins research
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
Ho Chi Minh City University of Technology
2011-2024
West Virginia University
2024
Lentigen Technology (United States)
2023-2024
University of California, Riverside
2008-2022
Kaiser Permanente
2022
Los Angeles Medical Center
2022
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2013-2022
FPT University
2021
Howard University
2020
Miller Children's & Women's Hospital
2013-2017
: Our objectives were to (1) determine the pharmacokinetic indices of vancomycin in pediatric patients; and (2) compare attainment 2 target exposures: area under curve (AUC) / minimum inhibitory concentration (MIC) ≥400 trough ≥15 mcg/mL.: The population-based modeling was performed using NONMEM 7.2 for children ≥3 months old who received ≥48 hours from 2003 2011. A 1-compartment model with first-order kinetics used estimate clearance, volume distribution AUC. Empiric Bayesian post hoc...
Abstract Objective Ankylosing spondylitis and related spondylarthritides are associated with HLA–B27, also intestinal inflammation, by unknown mechanisms. The folded HLA–B27 molecule is a trimer of heavy chain, β 2 ‐microglobulin (β m), short peptide. However, B27 chain has an unusual propensity to misfold trigger the unfolded protein response (UPR). This study was initiated test hypothesis that misfolding plays role in pathogenesis spondylarthritis. Methods Rats high transgene copy numbers...
Abstract Objective HLA–B27 predisposes to spondylarthritis by an unknown mechanism. A logical candidate mechanism is through recognition of B27 CD8+ T cells. The purpose this study was examine the effects a lack CD8 on that develops in B27/human β 2 ‐microglobulin (Huβ m)–transgenic rats. Methods missense mutation CD8a gene causes loss CD8α expression identified offspring male Sprague‐Dawley rat had been treated with mutagen N ‐ethyl‐ ‐nitrosourea. crossed into B27/Huβ m‐transgenic lines...
The objectives of this study were to: 1) evaluate the prevalence augmented renal clearance in critically ill pediatric patients using vancomycin clearance; 2) derive pharmacokinetic model that best describes patients; and 3) correlate with creatinine estimated by modified Schwartz or Cockcroft-Gault.Retrospective, two-center, cohort from 2003 to 2016.Clinical drug monitoring services PICUs at two tertiary care, teaching hospitals.Children 1 21 years old.None.Identify (vancomycin ≥ 130...
Background Chimeric antigen receptor (CAR) T-cell therapy target tyrosine kinase-like orphan 1 (ROR1) is broadly expressed in hematologic and solid tumors, however clinically-characterized ROR1-CAR T cells with single chain variable fragment (scFv)-R12 targeting domain failed to induce durable remissions, part due the immunosuppressive tumor microenvironment (TME). Herein, we describe development of an improved a novel, fully human scFv9 domain, augmented TGFβRIIDN armor protective against...
Abstract To test the hypothesis that HLA-B27 predisposes to disease by forming disulfide-linked homodimers, we examined rats transgenic for HLA-B27, mutant Cys67Ser or HLA-B7. In splenic Con A blasts from high transgene copy B27 lines develop inflammatory disease, anti-H chain mAb HC10 precipitated four bands of molecular mass 78–105 kDa and additional higher material, seen nonreducing SDS-PAGE. Upon reduction, all except one 78-kDa band resolved 44 kDa, size H monomer. The was found be...
Novel ion pair charge-transfer salts have been synthesized through the integration of metal chalcogenide cluster anions and methyl viologen cations. The new compounds show dramatically red-shifted UV−visible absorptions, which provide a way to control optical electronic properties chalcogenides, particularly in relation their potential applications solar cells.
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 aminopeptidase trims peptides in endoplasmic reticulum for binding MHC-I molecules. shows genetic epistasis with conferring AS. Male transgenic rats develop arthritis and serve as animal model of AS, whereas female B27 remain healthy. We used large scale quantitative mass spectrometry identify over 15,000 unique peptide...
A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including KDM4 demethylases.
Objective We undertook this study to examine the functional basis for epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA–B27 in experimental spondyloarthritis (SpA). Methods ERAP1–knockout rats were created using genome editing bred with HLA–B27/human β 2 ‐microglobulin–transgenic (HLA–B27‐Tg) HLA–B7‐Tg rats. The effects of ERAP1 deficiency on HLA allotypes determined immunoprecipitation immunoblotting, flow cytometry, allogeneic T cell proliferation assays, gene...
Cellular FLIP (Flice-like inhibitory protein) is critical for the protection against death receptor-mediated cell apoptosis. In macrophages, long (FLIP(L)) and short (FLIP(S)) mRNA was induced by tumor necrosis factor (TNF) alpha, mediated through NF-kappaB. However, we observed TNFalpha reduced protein level of FLIP(L), but not FLIP(S), at 1 2 h. Similar results were with lipopolysaccharide. The reduction FLIP(L) caspase 8, or JNK Itch, suppressed inhibition phosphatidylinositol...
Fibroblast growth factors (FGFs) negatively regulate long bone development by inhibiting the proliferation of chondrocytes that accumulate in G1 phase cycle following FGF treatment. Here we report also causes a striking but transient delay mitotic entry RCS inactivating cyclin B1-associated CDK1(CDC2) kinase. As consequence this inactivation, cells G2 for first 4-6 hours Cyclin B1/CDK1 activity is then restored and reach arrest. The reduced was accompanied increased CDK1 inhibitory...
Parenteral penicillin G (PENG) and oral amoxicillin (AMOX) are recommended as treatment for pediatric community-acquired pneumonia (CAP). With recent epidemiologic susceptibility data Streptococcus pneumoniae, the most common etiology of CAP, objective this study was to evaluate optimal dosing regimens PENG AMOX based on population pharmacokinetics linked current data.
Based on the data collected from 126 companies listed HCM city Stock Exchange (HOSE) during period 2006 - 2009, this empirical study investigates relationship between managerial ownership and corporate performance. It is found that there a strong non-linear performance ownership. The varies directly with when ratio less than 59.1%. However, over 59.1%, inversely nonlinear result of interactions alignment interests entrenchment: below certain value, managers have more incentive to work if...