A5101679999- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Pluripotent Stem Cells Research
- RNA modifications and cancer
Southern Medical University Shenzhen Hospital
2025
Harbin Medical University
2024
Abstract The process of induced pluripotent stem cells (iPSCs) reprogramming involves several crucial events, including the mesenchymal-epithelial transition (MET), activation genes, metabolic reprogramming, and epigenetic rewiring. Although these events intricately interact influence each other, specific element that regulates network remains unclear. Dux, a factor known to promote totipotency during from embryonic (ESC) 2C-like ESC (2CLC), has not been extensively studied in context iPSC...
In spite of its essential role in culture media, the precise influence lactate on early mouse embryonic development remains elusive. Previous studies have implicated accumulation medium affecting histone acetylation. Recent research has underscored lactate-derived lactylation as a novel epigenetic modification diverse cellular processes and diseases. Our investigation demonstrated that absence sodium resulted pronounced 2-cell arrest at late G2 phase embryos. RNA-seq analysis revealed...
This study aims to evaluate the distribution of preoperative corneal parameters obtained using Pentacam anterior segment analyzer in Chinese male and female patients with cataracts investigate correlation between these related factors. Preoperative examination data eyes 1,255 who underwent cataract surgery were retrospectively analyzed. The AXL was used extract measurements, total measurement average age 52.9 ± 21.3 years. mean simulated keratometry values curvature refractive power...
Recent studies have elucidated Nr5a2's role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is not critical for genome activation but vital the gene program between 4- and 8-cell stages. A significant gap exists experimental evidence regarding its function first lineage differentiation's pivotal period. In this study, we observed approximately 20% of embryos developed to blastocyst stage following ablation. However, these...