A5010437790- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Spaceflight effects on biology
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- High Altitude and Hypoxia
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Galectins and Cancer Biology
- Nutrition and Health in Aging
- Birth, Development, and Health
- Anesthesia and Neurotoxicity Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Calpain Protease Function and Regulation
- Muscle Physiology and Disorders
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
Sun Yat-sen Memorial Hospital
2021-2025
Sun Yat-sen University
2021-2025
Air Force Medical University
2011
The expanding production of engineered nanomaterials (ENMs) can eventually cause their increased release into and presence in aquatic ecosystems, potentially threatening the health organisms stability ecological environment. Generally, ENMs are repeatedly released real-world environments relatively low concentrations, affecting photosynthesis primary producers such as algae. However, knowledge regarding effects repeated exposure to on algal is still lacking. Herein, physiological responses...
Background Lenvatinib plus PD-1 inhibitors and interventional (LPI) therapy have demonstrated promising treatment effects in unresectable hepatocellular carcinoma (HCC). However, biomarkers for predicting the response to LPI remain be further explored. We aimed develop a radiomics model noninvasively predict efficacy of therapy. Methods Clinical data patients with HCC receiving were collected our institution. The clinical was built information. Nine machine learning classifiers tested...
Despite the remarkable progress of metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named non-alcoholic (NAFLD), remains poorly improved. Since increased oxidative stress and inflammation contribute to initiation progression disorders, vitamin C (VC), an antioxidant agent, might be a suitable treatment option for MAFLD. However, lack clinically confirmed benefits makes clinicians challenging recommend supplements MAFLD individuals.Herein, nationally representative...
Abstract Circular RNAs (circRNAs) have been implicated in tumorigenesis and progression of various cancers. However, the underlying mechanisms circRNAs hepatocellular carcinoma (HCC) not fully elucidated. Herein, a new oncogenic circRNA, hsa_circ_0070039 (circNUP54), was identified to be significantly upregulated HCC through circRNA sequencing. As verified 68 samples, circNUP54 overexpression correlated with aggressive cancerous behaviors poor outcomes. Moreover, function experiments showed...
Circular RNAs have been reported to play essential roles in the tumorigenesis and progression of various cancers. However, biological processes mechanisms involved hepatocellular carcinoma (HCC) remain unclear. Initial RNA-sequencing data qRT-PCR results our cohort showed that hsa_circ_0072309 (also called circLIFR) was markedly downregulated HCC tissues. Kaplan-Meier analysis indicated higher levels circLIFR patients correlated with favorable overall survival recurrence-free rates. Both...
Smith-like (LSM) family members play critical roles in multiple oncologic processes several types of malignancies. The study on LSM HCC might provide new insights into the tumorigenesis and therapeutic strategies HCC.The clinical significance biological functions were assessed through bioinformatics methods vitro studies. potential correlation between tumor immunity was also investigated using single sample gene set enrichment analysis (ssGSEA) ESTIMATE algorithm.LSM member overexpression...
Background and Aims: Cholecystectomy is the "gold standard" for treating diseases of gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), fibrosis or cirrhosis, are major causes morbidity mortality across world. However, association between cholecystectomy these still unclear. We assessed among US adults examined possible risk factors. Methods: This cross-sectional study used data from 2017 to 2018 National Health Nutrition Examination Survey, a population-based nationally...
Abstract Background Forkhead-box protein P1 (FOXP1) has been proposed to have both oncogenic and tumor-suppressive properties, depending on tumor heterogeneity. However, the role of FOXP1 in intrahepatic cholangiocarcinoma (ICC) not previously reported. Methods Immunohistochemistry was performed detect expression ICC normal liver tissues. The relationship between levels clinicopathological characteristics patients with evaluated. Finally, vitro vivo experiments were conducted examine...
This study was designed to clarify whether simulated microgravity-induced differential adaptational changes in cerebral and hindlimb arteries could be prevented by daily short-period restoration of the normal distribution transmural pressure across arterial vasculature either dorsoventral or footward gravitational loading. Tail suspension (Sus) for 28 days used simulate cardiovascular deconditioning due microgravity. Daily standing (STD) 1, 2, 4 h, +45 degrees head-up tilt (HUT) 2 h provide...
Solute carrier family 39 member 1 (SLC39A1) has been identified as a zinc ion transport protein that possesses oncogenic properties in various types of cancers. However, its potential function hepatocellular carcinoma (HCC) remains unknown. This study aimed to investigate the expression profile and mechanisms SLC39A1 HCC.SLC39A1 was analyzed using multiple databases. The clinical significance associated biological pathways were investigated bioinformatics analysis. Potential correlations...
Ferroptosis has been reported to regulate multiple biological behaviors. However, the prognostic and oncologic values of ferroptosis-related genes (FRGs) have not comprehensively elucidated in hepatocellular carcinoma (HCC). Here, we aimed construct FRGs-associated signature for stratification prognosis HCC patients.A list FRGs was generated from FerrDb. Public databases were used extract expression matrices clinical information. TCGA cohort randomly divided into a training set validation...
Abstract Hepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis treatment resistance. This study aimed to construct novel prognostic classifier investigate the degree of hypoxia immune profiles HCC. Patients with HCC from public databases were classified into three HIF-1α clusters according 16 reported HIF-1α-related genes. Then, an score system was constructed based on nine overlapping differentially expressed genes (ODEGs)...