A5046152606- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- Head and Neck Surgical Oncology
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Nuclear Receptors and Signaling
- Antibiotic Resistance in Bacteria
- GDF15 and Related Biomarkers
- Pneumonia and Respiratory Infections
- Cancer-related gene regulation
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024-2025
Shantou University
2018-2023
Shantou University Medical College
2018-2023
State Key Laboratory of Oncology in South China
2013
Sun Yat-sen University
2002
Sun Yat-sen University Cancer Center
2002
The most common mutations in epidermal growth factor receptor ( EGFR) are exon 19 deletions and 21 L858R mutations, both of which respond effectively to EGFR tyrosine kinase inhibitors. However, the efficacy inhibitors against rare remains controversial. Many patients eventually develop resistance Here, we encountered case a 62-year-old male with lung adenocarcinoma history hypertension, who harbored L858R/T790M/cis-C797S/L718Q compound mutation showed osimertinib. patient partial response...
TFPI-2 has been recognized as a potent tumor suppressor gene. Low expression of results in enhanced growth and metastasis variety human tumors. In the present study, we investigated mechanism responsible for suppressive effect TFPI-2. Overexpression decreased phosphorylation ERK1/2 translocation p-ERK1/2 from cytoplasm into nucleus, eventually resulted reduced cell proliferation. Immunoprecipitation assays identified myosin-9 actinin-4 TFPI-2-interacting proteins. Full-length was required...
Community-acquired pneumonia (CAP) presents a significant public health concern, necessitating timely and precise diagnosis. Metagenomic next-generation sequencing (mNGS) has shown promise as powerful tool for pathogen identification in infectious diseases. This study aimed to evaluate the diagnostic efficacy clinical applicability of mNGS immunocompromised patients with CAP compared culture method. included 168 patients. We used both conventional methods identify spectrum performance....
LncRNAs are emerging as important regulators of gene expression by controlling transcription in the nucleus and modulating mRNA translation cytoplasm. In this study, we reveal a novel function lncRNA SNHG15 mediating breast cancer cell invasion through regulating local CDH2 mRNA. We show that preferentially localizes at cellular protrusions or leading edge localization is directed IMP1, multifunctional protein involved many aspects RNA regulation. demonstrate also forms complex with...
Abstract GDF15 has been recently recognized as a tumor-suppressive gene. However, the underlying mechanism by which affects breast carcinogenesis is not well understood. Here, we showed that inhibitory effect of on cell proliferation was dependent nuclear localization protein. Dynamic translocation into nucleus altered expression number genes, including KISS-1, and resulted in inhibition growth invasive behavior. Using KISS-1 promoter-driven luciferase reporter chromatin immunoprecipitation...
Dyslipidemia plays a key role in metabolic syndrome (MS), intricately linked to type 2 diabetes mellitus (T2DM). This study aimed investigate the differences low-density lipoprotein cholesterol (LDL-C) subfraction levels between T2DM and with MS, identify risk factors associated disease. A total of 246 individuals diagnosed T2DM, including 144 patients 147 healthy subjects were recruited. All participants underwent comprehensive clinical evaluation. Lipoprotein analysis was performed using...