A5013911975- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Plant and Fungal Species Descriptions
- Botanical Research and Chemistry
- Phytochemistry Medicinal Plant Applications
- Pomegranate: compositions and health benefits
- Chemical synthesis and alkaloids
- Synthesis and bioactivity of alkaloids
- Enzyme Catalysis and Immobilization
- Phytochemical compounds biological activities
- Microbial Natural Products and Biosynthesis
- Chemistry and Chemical Engineering
- Fungal Biology and Applications
- African Botany and Ecology Studies
- Malaria Research and Control
- Legume Nitrogen Fixing Symbiosis
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Steroid Chemistry and Biochemistry
- Ethnobotanical and Medicinal Plants Studies
- Plant-based Medicinal Research
- Mass Spectrometry Techniques and Applications
- Natural Compounds in Disease Treatment
- Phytochemicals and Antioxidant Activities
Universidade Federal do Amazonas
2015-2024
Universidade da Amazônia
2018
Universidade do Estado do Amazonas
2016
Onychopetalum is an Amazonian botanical genus close-related with Bocageopsis and Unonopsis, whose species are used in traditional medicine.Although these genera widely investigated from the phytochemical viewpoint, knowledge about remains almost unexplored.In order to perform a comprehensive characterization of isoquinoline-derived alkaloids amazonicum, integrative approach based on alkaloid profile analysis by leaf spray mass spectrometry (LS-MS), followed robust dereplication through...
Abstract Introduction The Annonaceae family is known as a promising abundant source of secondary metabolites, especially annonaceous acetogenins, terpenoids and isoquinoline‐derived alkaloids. Although widely investigated from the phytochemical viewpoint, this still presents some largely unexplored genera, e.g. Bocageopsis . Objective To investigate alkaloid content pleiosperma Maas using direct infusion electrospray ionisation ion trap tandem mass spectrometry (ESI‐IT‐MS n ) analysis....
Polycarpol, a recurrent lanostane-type triterpene in Annonaceae family, was confirmed by thin layer chromatography and mass spectrometry analysis the aerial parts (twigs trunk barks) of Unonopsis duckei R.E. Fr., U. floribunda Diels, rufescens (Baill.) stipitata Onychopetalum amazonicum Fr. Bocageopsis pleiosperma Maas. Its chemotaxonomic significance discussed for these three genera, as well family. In addition, antimicrobial activity against several strains microorganisms evaluated first...
Bertholletia excelsa Bonpl.(Lecythidaceae) is a South American tree worldwide known for providing the Brazil nuts.In Amazon Region, B. found in monocultures, integrating agroforestries and raw materials food timber industries.Through application of an integrative analysis based on high-performance liquid chromatography coupled with diode array detector tandem mass spectrometry (HPLC-DAD-MS/MS) nuclear magnetic resonance (NMR) techniques, present study showed that bark biomass residues...
Unonopsis (Annonaceae) is a neotropical genus constituted by nearly fifty species, with fifteen described in Brazil.In the state of Amazonas seven species are found, including U. guatterioides, which displays problems from botanical viewpoint.Previous studies showed this as promising source aporphinoid alkaloids.In order to investigate potential leaf alkaloid fingerprint for chemotaxonomic approaches, twelve specimens, representing five commonly found were subjected acid-base partitioning...
(+)‐ N ‐formylnorglaucine ( 1 ), an aporphine alkaloid containing a formyl group linked to the heterocyclic nitrogen, was isolated from leaves of Unonopsis stipitata , Amazon medicinal plant. The chemical structure characterized based on 1D‐ and 2D‐ NMR spectroscopy HR‐ESI‐MS . spectra revealed that is composed two rotamers 1a 1b ) in ratio approximately 2:1. In addition, fragmentation behavior displayed unusual pattern compared regular alkaloids. Thus, this compound reported for first time...
The genus Penicillium is among the most promising alkaloid-producing fungal and therefore plays an important role in terms of producing molecules with biotechnological potential. Thus, order to identify fungi, 25 endophytic strains previously isolated from Amazon medicinal plants were subject integrative approach based on direct infusion positive electrospray ionization mass spectrometry (ESI-MS) principal component analysis (PCA). multivariate pointed paxiline (1), glandicoline B (2),...
The essential oils from leaves, twigs and trunk bark of Onychopetalum amazonicum R.E. Fr. (Annonaceae), obtained by hydrodistillation, were analysed GC GC-MS, also evaluated for in vitro antimicrobial activity. Forty-one compounds, which correspond to 75.0-92.2% the oil components, identified. Major compounds sesquiterpenes, including (E)-caryophyllene, caryophyllene oxide, spathulenol, α-gurjunene, allo-aromadendrene α-epi-cadinol. activities against four bacteria strains five pathogenic...
Strychnos peckii (Loganiaceae) is an important active ingredient in curare poisons the Amazon rainforest. Although previous studies have identified this species as a promising source of monoterpene indole alkaloids (MIAs), knowledge about other natural products still scarce. Thus, to detect and guide isolation unprecedented bioactive compounds from leaves S. , untargeted high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) analysis was performed leaf aqueous...