Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that co-opt the cell's natural proteasomal degradation mechanisms to degrade undesired proteins. A challenge associated with PROTACs is time and resource-intensive optimization; thus, development of high-throughput platforms for their synthesis biological evaluation required. In this study, we establish an ultra-high-throughput experimentation (ultraHTE) platform PROTAC synthesis, followed by direct addition crude...

Advanced driver assistance systems (ADAS) seek to provide drivers and passengers of automotive vehicles increased safety comfort. Original equipment manufacturers are integrating developing for distance keeping, lane keeping changing other functionalities. The modern automobile is a complex system systems. How the functionalities advanced implemented coordinated across vehicle generally not made available wider research community by developers manufactures. This paper seeks begin filling...

The expansion of the Internet Things (IoT) has resulted in a complex cyber-physical system systems that is continually evolving. With ever more being developed and changed there been an increasing reliance on simulation as vital part design process. There also growing need for integration co-simulation order to analyse interactions between components. To this end we propose Simulation (IoS) extension IoT can be used meet these needs. IoS allows multiple heterogeneous simulations integrated...

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report synthesis via palladium-catalyzed C(sp3)–C(sp3) coupling between (chloromethyl)aryls air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation followed by millimolar-scale reaction...

The ability to reliably distribute simulations across a distributed system and seamlessly integrate them as workflow regardless of their level abstraction is critical improving the quality product manufacturing. This paper presents DIVIDER architecture for managing maintaining real-time performance integrated through SOAs. described approach captures features present in complex patterns such asynchronous arbitrary cycles estimates worst case execution time context interfering environment.

Continuing professional education (CPE) refers to the ongoing, structured and unstructured learning educational opportunities that are pursued by particular groups their members. This paper argues CPE needs discard its traditional, conservative mantle assume a new agenda more consistent with emancipatory transformative imperatives associated organization. To guide this development, set of philosophical principles is provided these grounded in work two theorists, Paulo Freire Antonio Gramsci....

Academic theorists often discount theories which teachers and administrators rely on in everyday practice. Common sense, experience native wit are seen as poor guides for decision-making. This paper arguesfor theory to be developed from the practitioner's craft - that 'works'!

ABSTRACT: Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that co opt the cell’s natural proteasomal degradation mechanisms to selectively tag and degrade undesired proteins. However, a challenge associated with PROTACs is difficult optimisation required identify new degraders, thus development of high-throughput platforms for their synthesis biological evaluation required. In this study, we establish an ultra experimentation (ultraHTE) platform PROTAC synthesis,...

(1990). Practice Teaching in New Zealand: policies, practices and problems. South Pacific Journal of Teacher Education: Vol. 18, No. 1, pp. 19-26.

This is the first of two papers detailing findings from a tecent New Zealand study socialisation and induction primary school teachers during their year teaching. Background information about this methodology used, as well discussion four seven major categories data to emerge study, will constitute basis present article. In second paper, final three be discussed, along with practical application have for wide range personnel connected training professional development beginning in Australasia.

High-throughput chemistry (HTC) and direct-to-biology (D2B) platforms allow for plate-based compound synthesis biological evaluation of crude mixtures in cellular assays.

ABSTRACT: Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that co opt the cell’s natural proteasomal degradation mechanisms to selectively tag and degrade undesired proteins. However, a challenge associated with PROTACs is difficult optimisation required identify new degraders, thus development of high-throughput platforms for their synthesis biological evaluation required. In this study, we establish an ultra experimentation (ultraHTE) platform PROTAC synthesis,...

Aboriginal Studies at the Canberra College of Advanced Education has achieved a reputation as being one most favoured series units available. Although it immense popularity within Teacher Education, also attracts large number students from other schools college. Its level appeal is reflected in content two Unit I course aims introducing to pre-contemporary understanding Aboriginal, his kinship, religion, habitat, livelihood, art, music and pre-history. Coincidentally, 2 examines problems...

What is the economic value of UK hospitality industry and wider tourism industry? How many people does each employ? Estimates from different sources provide wildly differing answers, leading to confusion misunderstanding. Here, authors, using information appearing in a new publication (Hospitality Digest 2014, 189 pages (PDF format only), published by Institute Hospitality, ( www.instituteofhospitality.org ). It provides over 100 tables on size structure tourism, hotel, food service...

Technology assimilation is a complex process that requires effort from both engineering and business professionals. However, in practice, technology generally supported with single factor assessment tool, such as the readiness levels (TRLs) categorization. This paper argues this approach not sufficient environment. The TRL do provide various stakeholders holistic viewpoint are designed to allow consideration of different types way can be broadly understood accepted by all. approaches problem...

ABSTRACT As the task of selecting an appropriate textbook for a course is difficult this article presents procedure (checklist) which instructors might adopt to assist in their decision making. The Textbook Selection Checklist developed from strong empirical base and has been trialled assess relative merits introductory educational psychology textbooks published since 1975. results assessment are provided implications students, instructors, publishers discussed.