A5058116444- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Menopause: Health Impacts and Treatments
- Diet and metabolism studies
- Air Quality and Health Impacts
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Climate Change and Health Impacts
- Noise Effects and Management
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Biochemical effects in animals
Albany Medical Center Hospital
2021-2024
University at Albany, State University of New York
2023
Albert Einstein College of Medicine
2019
Montefiore Medical Center
2017-2019
Abstract Background Damage to the cerebral vasculature can lead vascular contributions cognitive impairment and dementia (VCID). A reduction in blood flow brain leads neuropathology, including neuroinflammation white matter lesions that are a hallmark of VCID. Mid-life metabolic disease (obesity, prediabetes, or diabetes) is risk factor for VCID which may be sex-dependent (female bias). Methods We compared effects mid-life between males females chronic hypoperfusion mouse model C57BL/6J mice...
About two-thirds of those with Alzheimer's disease (AD) are women, most whom post-menopausal. Menopause accelerates dementia risk by increasing the for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic (obesity, diabetes/prediabetes) is a well-known factor dementia. A high fat diet can lead to poor health in both humans rodents.
Objective: To evaluate how asthma-related emergency department visits (AREDV), air pollutant levels, pollen counts, and weather variables changed from 2001 to 2008 in the Bronx, NY. Methods: 42,065 daily AREDV values (1 January 31 December 2008) were collected using our institution's Clinical Looking Glass software. Daily of sulfur dioxide (SO2), carbon monoxide (CO), ozone (O3), nitrogen (NO2), temperature, humidity obtained National Climatic Data Center's Bronx station. tree counts Armonk...
Alzheimer's disease (AD) is the leading cause of disability and 5th death in people over 65 years age. Approximately 2/3 AD patients are women, most whom postmenopausal. Menopause linked with cognitive changes women: younger age at menopause associated worse outcomes. Moreover, accelerates mid-life risk factors for dementia, by increasing cardiovascular cerebrovascular metabolic which itself a factor dementia. We have previously shown that female 3xTg-AD mice more greatly impacted...
Abstract About two-thirds of those with Alzheimer’s disease (AD) are women, most whom post-menopausal. Menopause accelerates the risk for dementia by increasing metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic (e.g. obesity, diabetes, or prediabetes) is a well-known factor dementia. A high fat diet can lead to poor health in both humans rodents. The goal this study was determine effects menopause on outcomes App NL-F knock-in mouse model disease. To menopause, we...
Abstract Background Up to 80% of Alzheimer’s Disease (AD) patients suffer from concurrent vascular contributions cognitive impairment and dementia (VCID) resulting in multi‐etiology dementia. VCID (the 2nd leading cause dementia) is more common men throughout most the lifespan. while majority (approximately 2/3) are women. Ageing a main risk factor which may act through depletion sex hormones. Both testosterone, men, estrogen, women, have been shown be neuroprotective. In this study we...
Abstract Background Neuroinflammation plays a central role in the progression of vascular contributions to cognitive impairment and dementia (VCID). Unfortunately, anti‐inflammatory therapeutics have proven insufficient so far at ameliorating VCID. This may be because broadly suppressing inflammation prohibits its beneficial functions. Instead, supporting endogenous resolving programs prove more effective. Mid‐life metabolic disease is major risk factor for VCID, particularly women....