A5044520638- Menopause: Health Impacts and Treatments
- Frailty in Older Adults
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Estrogen and related hormone effects
- Regulation of Appetite and Obesity
- Hip and Femur Fractures
- Diet and metabolism studies
- Cancer-related cognitive impairment studies
- Adipose Tissue and Metabolism
- Renal Transplantation Outcomes and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical effects in animals
- Organ Transplantation Techniques and Outcomes
- Circadian rhythm and melatonin
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Organ Donation and Transplantation
- Orthopaedic implants and arthroplasty
Albany Medical Center Hospital
2021-2025
University at Albany, State University of New York
2023
Association of Organ Procurement Organizations
2021
The overall number of pancreas transplants decreased slightly, from 1027 in 2018 to 1015, 2019, up a nadir 947 2015. However, the simultaneous pancreas-kidney (SPKs) increased with corresponding drop pancreas-after-kidney (PAKs) and alone (PTAs). New waitlist registrations 1772 1606 2018. This was predominately driven by SPK listings, those type 2 diabetes. Waiting time for months, median 12 months but PTA recipient mean waiting remained substantially higher, at 24 Both short- long-term...
Menopause is an endocrine shift leading to increased vulnerability for cognitive impairment and dementia risk factors, in part due loss of neuroprotective circulating estrogens. Systemic replacement estrogen post-menopause has limitations, including estrogen-sensitive cancers. A promising therapeutic approach therefore might be deliver only the brain. We examined whether we could enhance performance by delivering exclusively brain ovariectomized mice (a surgical menopause model). treated...
Background Frailty has been associated with a greater risk of complications and higher treatment costs for various medical conditions surgical procedures. The Modified Index, which analyzes five or six comorbidities, helps grade the severity patient’s frailty. Patients frailty, as recognized by this index, are more likely to face adverse events after total shoulder arthroplasty (TSA). However, these modified indices often do not consider less common that contribute As such, we believe...
Abstract Background Damage to the cerebral vasculature can lead vascular contributions cognitive impairment and dementia (VCID). A reduction in blood flow brain leads neuropathology, including neuroinflammation white matter lesions that are a hallmark of VCID. Mid-life metabolic disease (obesity, prediabetes, or diabetes) is risk factor for VCID which may be sex-dependent (female bias). Methods We compared effects mid-life between males females chronic hypoperfusion mouse model C57BL/6J mice...
About two-thirds of those with Alzheimer's disease (AD) are women, most whom post-menopausal. Menopause accelerates dementia risk by increasing the for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic (obesity, diabetes/prediabetes) is a well-known factor dementia. A high fat diet can lead to poor health in both humans rodents.
ABSTRACT Menopause is a major endocrinological shift that leads to an increased vulnerability the risk factors for cognitive impairment and dementia. This thought be due loss of circulating estrogens, which exert many potent neuroprotective effects in brain. Systemic replacement estrogen post-menopause has limitations, including estrogen-sensitive cancers. A more promising therapeutic approach therefore might deliver only brain thus limiting adverse peripheral side effects. We examined...
Alzheimer's disease (AD) is the leading cause of disability and 5th death in people over 65 years age. Approximately 2/3 AD patients are women, most whom postmenopausal. Menopause linked with cognitive changes women: younger age at menopause associated worse outcomes. Moreover, accelerates mid-life risk factors for dementia, by increasing cardiovascular cerebrovascular metabolic which itself a factor dementia. We have previously shown that female 3xTg-AD mice more greatly impacted...
Abstract About two-thirds of those with Alzheimer’s disease (AD) are women, most whom post-menopausal. Menopause accelerates the risk for dementia by increasing metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic (e.g. obesity, diabetes, or prediabetes) is a well-known factor dementia. A high fat diet can lead to poor health in both humans rodents. The goal this study was determine effects menopause on outcomes App NL-F knock-in mouse model disease. To menopause, we...
Abstract Background Up to 80% of Alzheimer’s Disease (AD) patients suffer from concurrent vascular contributions cognitive impairment and dementia (VCID) resulting in multi‐etiology dementia. VCID (the 2nd leading cause dementia) is more common men throughout most the lifespan. while majority (approximately 2/3) are women. Ageing a main risk factor which may act through depletion sex hormones. Both testosterone, men, estrogen, women, have been shown be neuroprotective. In this study we...