A5061880531- Hypothalamic control of reproductive hormones
- Neuroendocrine regulation and behavior
- Ovarian function and disorders
- Plant Reproductive Biology
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Cancer-related cognitive impairment studies
- Menopause: Health Impacts and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Neuropeptides and Animal Physiology
- Maternal Mental Health During Pregnancy and Postpartum
- Attachment and Relationship Dynamics
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Reproductive Biology and Fertility
- Sex and Gender in Healthcare
- Nerve injury and regeneration
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Obstructive Sleep Apnea Research
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Ultrasound and Hyperthermia Applications
- Evolutionary Psychology and Human Behavior
Albany Medical Center Hospital
2021-2024
University of California, San Diego
2015-2023
University at Albany, State University of New York
2023
Twitter (United States)
2022
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
University of California System
2017
Emory National Primate Research Center
2013-2014
Kisspeptin, encoded by Kiss1, stimulates GnRH neurons to govern reproduction. In rodents, estrogen-sensitive kisspeptin in the anterior ventral periventricular nucleus and neighboring are thought mediate sex steroid-induced positive feedback induction of preovulatory LH surge. These coexpress estrogen progesterone receptors display enhanced neuronal activation during However, although regulation has been well studied, role signaling regulating is unknown. Here we tested whether action...
Abstract Stress elicits activation of the hypothalamic-pituitary-adrenal axis, which leads to enhanced circulating glucocorticoids, as well impaired gonadotropin secretion and ovarian cyclicity. Here, we tested hypothesis that elevated, stress-levels glucocorticoids disrupt cyclicity by interfering with preovulatory sequence endocrine events necessary for LH surge. Ovarian was monitored in female mice implanted a cholesterol or corticosterone (Cort) pellet. Cort, but not cholesterol,...
Throughout most of the ovulatory cycle, estrogen negative feedback restrains GnRH neuronal system. Just before ovulation, however, is removed to permit stimulation preovulatory GnRH/LH surge (positive feedback) by circadian clock in suprachiasmatic nucleus (SCN). The mammalian ortholog avian gonadotropin-inhibitory hormone, RFamide-related peptide 3 (RFRP-3), participates circadian-timed removal LH surge. present study examined specific neurochemical means which SCN controls RFRP-3 activity...
Abstract In females, ovarian estradiol (E2) exerts both negative and positive feedback regulation on the neural circuits governing reproductive hormone secretion, but cellular molecular mechanisms underlying this remain poorly understood. rodents, estrogen receptor α–expressing kisspeptin neurons in hypothalamic anteroventral periventricular region (AVPV) are prime candidates to mediate E2 induction of preovulatory gonadotropin-releasing luteinizing (LH) surges. stimulates AVPV Kiss1...
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction stimulating GnRH secretion. Neurons synthesizing kisspeptin are predominantly located in the hypothalamic anteroventral periventricular (AVPV) and arcuate nuclei, but smaller neuronal populations also reside extrahypothalamic brain regions, such as medial amygdala (MeA). In adult rodents, estradiol (E2) increases Kiss1 expression MeA, AVPV. However, unlike AVPV nuclei neurons, little else is currently known about...
Menopause is an endocrine shift leading to increased vulnerability for cognitive impairment and dementia risk factors, in part due loss of neuroprotective circulating estrogens. Systemic replacement estrogen post-menopause has limitations, including estrogen-sensitive cancers. A promising therapeutic approach therefore might be deliver only the brain. We examined whether we could enhance performance by delivering exclusively brain ovariectomized mice (a surgical menopause model). treated...
Limb and respiratory muscle (diaphragm) strength fatiguability have been extensively studied in man are known to vary with age sex. However, contrast limb muscles the diaphragm, force characteristics not upper airway muscles. This study examines hypotheses that tongue protrusion or fatiguability, determined by properties of intrinsic genioglossus, may change be reduced males compared females. A transducer was used compare maximal (Fmax) 81 86 females matched for (mean+/-SD, 43+/-19 yrs,...
Research on oxytocin (OT) has revealed a substantial involvement of this neuropeptide in social cognition processes and attachment behavior.The rationale the present project was to decipher differential role OT basic towards non-erotic stimuli vs. reproduction-related human subjects.In randomized double-blind repeated-measures cross-over design, N = 82 participants were investigated twice received either intranasal or placebo at first assessment followed by second assessment. Participants...
Abstract The neuropeptide kisspeptin, encoded by Kiss1 , regulates reproduction stimulating GnRH secretion. Kiss1- syntheizing neurons reside primarily in the hypothalamic anteroventral periventricular (AVPV/PeN) and arcuate (ARC) nuclei. AVPV/PeN are sexually dimorphic, with females expressing more than males, participate estradiol (E 2 )-induced positive feedback control of In mice, most cells coexpress tyrosine hydroxylase (TH), rate-limiting enzyme catecholamine synthesis (in this case,...
Abstract The peptide kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Evidence indicates that signaling is also important for body weight (BW) metabolism. We recently reported Kiss1r KO mice develop obesity, along with reduced metabolism energy expenditure, independent of estradiol levels. Outside the brain, expressed in several metabolic tissues, including brown adipose tissue (BAT), but it unknown which specific responsible phenotype KOs. first determined...
ABSTRACT The current study examined the effects of neonatal amygdala lesions on mother–infant interactions in rhesus monkeys reared large species‐typical social groups. Focal observations were collected their group for first 12 months postpartum infants that had received (Neo‐A) at 24–25 days age and control infants. Early resulted subtle behavioral alterations. Neo‐A females exhibited earlier emergence independence from mother than did females, spending more time away mother, whereas males...
The current study examined the long-term effects of neonatal amygdala (Neo-A) lesions on brain corticotropin-releasing factor (CRF) systems and hypothalamic-pituitary-adrenal (HPA) axis function male female prepubertal rhesus monkeys. At 12-months-old, CSF levels CRF were measured HPA activity was characterized by examining diurnal cortisol rhythm response to pharmacological challenges. Compared with controls, Neo-A animals showed higher secretion throughout day, females also levels....
Kisspeptin, encoded by Kiss1, activates reproduction stimulating GnRH neurons. Although most Kiss1 neurons are located in the hypothalamus, smaller populations also reside medial amygdala (MeA), bed nucleus of stria terminalis (BnST), and lateral septum (LS). However, very little is known about regulation function these extra-hypothalamic This study focused on roles interactions two signaling factors, estradiol (E2) GABA, to stimulate inhibit, respectively, expression. First, using estrogen...
Reproduction is regulated through the hypothalamic-pituitary-gonadal (HPG) axis, largely via action of kisspeptin neurons in hypothalamus. Importantly, Kiss1 have been identified other brain regions, including medial amygdala (MeA). Though MeA implicated regulating aspects both reproductive physiology and behavior, as well non-reproductive processes, functional roles are unknown. Additionally, besides their stimulation by estrogen, little known about how regulated. Using a RiboTag mouse...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression a pituitary gonadotrope cell model primary gonadotropes, we show GLUT1-dependent stimulation glycolysis, but not mitochondrial respiration, by reproductive neuropeptide GnRH. GnRH increases translocation extracellular membrane....
ABSTRACT Menopause is a major endocrinological shift that leads to an increased vulnerability the risk factors for cognitive impairment and dementia. This thought be due loss of circulating estrogens, which exert many potent neuroprotective effects in brain. Systemic replacement estrogen post-menopause has limitations, including estrogen-sensitive cancers. A more promising therapeutic approach therefore might deliver only brain thus limiting adverse peripheral side effects. We examined...