A5035547658- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Hypothalamic control of reproductive hormones
- Redox biology and oxidative stress
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
University of California, San Diego
2019-2020
A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is episodic secretion pituitary gonadotropin hormones LH and FSH by anterior gonadotropes. Hormone dictated pulsatile stimulation, with GnRH released hypothalamic neurons that bind activate G protein-coupled receptor expressed synthesis gonadotropins are influenced amplitude frequency stimulation; variation in either affects proportion secreted differential regulation hormone subunit gene expression....
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression a pituitary gonadotrope cell model primary gonadotropes, we show GLUT1-dependent stimulation glycolysis, but not mitochondrial respiration, by reproductive neuropeptide GnRH. GnRH increases translocation extracellular membrane....
Women with polycystic ovary syndrome (PCOS) have a high prevalence of metabolic comorbidities including dyslipidemia, syndrome, and type 2 diabetes mellitus. However, the impact systemic dysregulation on reproduction is not completely understood. In particular, women PCOS elevated androgen as well blood glucose, insulin, free fatty acids. These circulating factors can directly interact gonadotrope cells within highly vascular pituitary. We therefore postulate that gonadotropes “sense”...
Abstract Reproduction requires intensive energy expenditure, and availability impacts the function of reproductive endocrine HPG-axis. Accordingly, axis is suppressed during hypoglycemia. Circulating blood glucose can directly interact with gonadotropes within highly vascular pituitary. Therefore, it possible that may sense via presence in circulation integrate this status input from GnRH neurons to regulate hormone production. Gonadotropes dominantly express transporter 1 (GLUT1) increase...