A5057939118- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- TGF-β signaling in diseases
- Adrenal and Paraganglionic Tumors
- Reproductive Biology and Fertility
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Neuroendocrine Tumor Research Advances
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Neuroblastoma Research and Treatments
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- Pancreatic and Hepatic Oncology Research
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- RNA Research and Splicing
- Birth, Development, and Health
- Asthma and respiratory diseases
- Kruppel-like factors research
- Parasitic Diseases Research and Treatment
Okayama University
2007-2023
Okayama University Hospital
2016-2023
University of California, San Diego
2017-2020
Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous regulate release, including aspects pulsatile luteinizing hormone (LH) secretion, remain unknown. Because animal models are valuable for...
A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived complexes deposit in glomerular mesangial cells, eliciting nephropathy. Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of 46-year-old Japanese man developed 29 years ago, following tonsillectomy. As a result, normal urinalysis was obtained. The patient previously suffered...
Recent studies have shown that bone morphogenetic proteins (BMPs) are important regulators in the pituitary–gonadal endocrine axis. We here investigated effects of BMPs on GNRH production controlled by estrogen using murine GT1-7 hypothalamic neuron cells. cells expressed receptor α (ERα; ESR1 as listed MGI Database), ERβ (ESR2 BMP receptors, SMADs, and a binding protein follistatin. Treatment with BMP2 BMP4 had no effect Gnrh mRNA expression; however, BMP6 BMP7 significantly increased...
A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is episodic secretion pituitary gonadotropin hormones LH and FSH by anterior gonadotropes. Hormone dictated pulsatile stimulation, with GnRH released hypothalamic neurons that bind activate G protein-coupled receptor expressed synthesis gonadotropins are influenced amplitude frequency stimulation; variation in either affects proportion secreted differential regulation hormone subunit gene expression....
Osteoblasts undergo differentiation in response to various factors, including growth factors and steroids. Bone mass is diminished androgen- and/or hormone (GH)-deficient patients. However the functional relationship between androgen GH, their combined effects on bone metabolism, remains unclear. Here we investigated mutual of GH osteoblastic marker expression using mouse myoblastic C2C12 osteoblast-like MC3T3-E1 cells. Combined treatment with dihydrotestosterone (DHT) enhanced BMP-2-induced...
Biological rhythms lie at the center of regulatory schemes that control many aspects living systems. At cellular level, meaningful responses to external stimuli depend on propagation and quenching a signal maintain vigilance for subsequent stimulation or changes serve shape modulate response. The hypothalamus-pituitary-gonad endocrine axis controls reproductive development function relies through rhythmic stimulation. Central this is pulsatile gonadotropes by hypothalamic neurons episodic...
A 34-year-old man with 22q11.2 deletion syndrome (DiGeorge syndrome) concurrently suffered from myopathy and eosinophilic pneumonia shortly after receiving daptomycin (DAP) for right-sided infective endocarditis. The simultaneous occurrence of these phenomena in relation to DAP therapy has not been previously well described. An allergic reaction was suspected as a possible etiology DAP-related complications. This case highlights the need close observation order detect both musculoskeletal...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression a pituitary gonadotrope cell model primary gonadotropes, we show GLUT1-dependent stimulation glycolysis, but not mitochondrial respiration, by reproductive neuropeptide GnRH. GnRH increases translocation extracellular membrane....
An emerging body of evidence supports the concept that pituitary is a site for integration multiple physiological and metabolic signals inform modulate endocrine pathways. Multiple mediators energy balance adiposity are known to impinge on neuroendocrine axis regulating reproduction. Observations in humans show obesity correlated with decreased gonadotropin secretion, studies have also suggested sensitivity stimulation by gonadotropin-releasing hormone (GnRH) obese individuals. Free fatty...
Gonadotropin secretion, which is elicited by GnRH stimulation of the anterior pituitary gonadotropes, a critical feature reproductive control and maintenance fertility. In addition, activation receptor (GnRHR) regulates transcription translation multiple factors that regulate signaling response synthesis gonadotropins. results in broad redistribution mRNA between active inactive polyribosomes within cell, but mechanism not known. The RNA-binding protein embryonic lethal, abnormal vision,...
We herein describe a case of Wuchereria bancrofti infection in previously healthy 37-year-old Nepalese man. The patient presented with history milky urine subsequent acute urinary retention lasting for few days. presence microfilariae was confirmed on both peripheral blood and smears obtained at midnight. He conservatively treated diethylcarbamazine combined doxycycline. Filariasis endemic southern parts Japan, although it has been eradicated. Clinicians should remember filariasis as...
Introduction While it is well known that thyroid function may affect kidney function, the transition of chronic disease (CKD) status before and after treatment for disorders, as factors affecting this change, remains to be explored. In present study, we focused on change in their during both hyperthyroidism hypothyroidism. Methods Eighty-eight patients with fifty-two hypothyroidism were enrolled a retrospective longitudinal case series analyze changes disorders. Results Along improvement...
Objective To analyze the clinical and endocrine characteristics of patients with primary adrenal lymphoma.