A5105068361- Cancer, Lipids, and Metabolism
- Chromatography in Natural Products
- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Bone health and treatments
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Graphite, nuclear technology, radiation studies
- Radiomics and Machine Learning in Medical Imaging
- Radioactive Decay and Measurement Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Toxin Mechanisms and Immunotoxins
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Caveolin-1 and cellular processes
- Plant-Derived Bioactive Compounds
- RNA Research and Splicing
- Forest ecology and management
- Antimicrobial Peptides and Activities
- Additive Manufacturing and 3D Printing Technologies
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
National Institute of Technology Hamirpur
2025
Central University of Rajasthan
2015-2024
Post Graduate Institute of Medical Education and Research
2023
Command Hospital
2022
University High School
2019-2021
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types. Few studies documented that there was decreased level of LDL and total cholesterol blood serum metformin users. Based on these views, this study aimed to determine if exhibits by alleviating cells. The present found treatment breast MDA-MB-231 cells with significantly content concomitant inhibition regulatory genes (e.g., HMGCoR, LDLR SREBP1). Metformin cell viability, migration stemness...
Many risk factors such as smoking and change of life style have been shown to promote genetic adaptive epigenetic changes responsible for tumorigenesis. This study brings environmental temperature a cancer causing factor light. The mortality rate (CMR) country was correlated with 17 different variables. Multivariate analysis total 188 countries found that the average annual (AAT) might significant contribution death when compared other alcohol meat consumption. Univariate negative...
Modern treatment strategies provide better overall survival in cancer patients, primarily by controlling tumor growth. However, off-target and systemic toxicity, recurrence, resistance to therapy are still inadvertent hurdles current regimens. Similarly, metastasis is another deadly threat patients suffering from cancer. This has created an urgent demand come up with new drugs having anti-metastatic potential minimum side effects. Thus, this study was aimed at exploring the...
Vitrimers are a class of advanced polymeric materials characterized by their dynamic covalent networks, which offer unique properties such as self-healing, reprocessability, and shape memory. The integration vitrimers into 3D printing technologies presents significant advancement in the field additive manufacturing, offering numerous benefits over traditional thermoplastics thermosets. use printing, leverages ability to be cured reformed under specific conditions, exposure light or heat....
Previous reports have documented that cholesterol-lowering simvastatin prevented osteolytic metastasis of breast cancer in animal model which cells were placed into blood circulation. Thus, treatment might a preventive effect inhibiting osteoclast activity metastatic bone microenvironment. This study both and MBCD (cholesterol depleting drug) blocked the cancer-induced TRAP MMP activity, expressions various osteoclastogenic genes (TRAP, Cathepsin K, NFATc1) pre-osteoclast RAW264.7 cells,...
Cancer incidence and/or mortality among individuals varies with diet, socio-culture, ethnicity, race, gender, and age. Similarly, environmental temperature modulates many biological functions. To study the effect of environment on cancer incidence, US population was selected. Because, county-wise rate data various anatomical site–specific cancers different races/ethnicities for both males females are available. Moreover, differences amongst aforementioned factors much less, as compared to...
Microorganisms thrive in extreme environments and are known for synthesizing valuable metabolites. Salt-loving microorganisms can flourish saline which inhibit the growth of other microbial life, they possess potential to produce stable novel biomolecules use biotechnological applications, including anticancer compounds. Sambhar Lake is largest inland soda lake India an appropriate habitat halophilic bacterial archaeal strains terms diversity production bioactive In present study, a...
Abstract N ‐acyl dopamines (NADAs) are bioactive lipids of the endovanilloid family with known cytotoxicity for cancer cells; however, available data on participation endovanilloids in epithelial–mesenchymal transition (EMT) and stemness controversial. This study unveils inhibitory role ‐arachidonoyl dopamine (AA‐DA), a typical representative NADA family, breast cell migration, EMT, stemness. AA‐DA treatment also led to decrease cholesterol biosynthesis gene expressions, addition exogenous...
Many factors such as smoking, obesity, and high fat have been either directly or indirectly linked to cancer deaths and/or incidences. Similarly, abnormal serum cholesterol levels assigned a risk factor for cancer, but some studies show discrepant result. To resolve this discrepancy, we analyzed data of 166 countries. Univariate analysis showed positive correlation between average total (ATC) overall mortality rate (CMR) [tau = 0.277, z 5.19, p < 0.0001]. It was also observed that similar...
Microcalcification seems to be an assurance signature for the prediction of breast cancer malignancy. However, neither systematic study deciphering molecular mechanism mammary microcalcification has yet been conducted, nor a mechanistic performed find out its prevention. Thus, this firstly aimed at determining if malignant tissues/metastatic cells exhibit elevated intrinsic osteoblast-like potential responsible driving pathological in tumors. Here, tumor sample analysis showed higher levels...
Abstract The unobtrusive cold environmental temperature can be linked to the development of cancer. This study, for first time, envisaged stress‐mediated induction a zinc finger protein 726 (ZNF726) in breast However, role ZNF726 tumorigenesis has not been defined. study investigated putative cancer tumorigenic potency. Gene expression analysis using multifactorial databases predicted overexpression various cancers, including Experimental observations found that malignant tissues and highly...
This manuscript is specifically focused on the dead time detection of G.M. Counter by optimizing most optimum values operating voltage using different radioactive sources. We have estimated and attenuation radiation in materials (at two voltages) samples. The emitted from a sample never influenced surrounding environmental conditions. But it now evident that count highly sensitive choice voltage, temperature, Tube design, fatigue, other external factors. Any variation these factors affects...
Amberboa ramosa Roxb. (Asteraceae), commonly known as “Badaward”, has been used for the treatment of tumors from ancient times. In this study, we aimed to scientifically authenticate use A. breast cancer treatment. The whole plant fractions were evaluated their cytotoxic properties against MDA-MB-231 cell lines. Among these fractions, Pet. ether, ethyl acetate, and ethanolic exhibited considerable levels cytotoxicity cells with [Formula: see text] values 78.55, 90.60, 92.92 text]g/mL,...
Abstract A preliminary cum. exploratory research is carried out to explore the few selected areas within Chandigarh introspect our living and surrounding environmental conditions that whether it’s safe from radiation perspective or not. The here in this paper signifies highly energetic radioactive emitted inside nucleus. motivation for performing work ensure safety of beings exposure. Effects radiation, especially case prolonged exposure, can be extremely dangerous even fatal near future if...
Objectives: Globally, breast cancer is the second most frequently diagnosed malignancy just behind lung cancer, accounting for over 2 million cases each year. It commonly worldwide and common among females in India. The role of whole-body positron emission tomography (WBPET) all still not clear. This pilot study was undertaken to whether there any change management using WBPET scan patients irrespective stage? Materials Methods: We retrospectively reviewed data 43 with invasive who were...