Naama Darzi
A5058166391- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Pancreatitis Pathology and Treatment
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Redox biology and oxidative stress
- interferon and immune responses
- RNA Interference and Gene Delivery
- Glutathione Transferases and Polymorphisms
Weizmann Institute of Science
2022-2025
Abstract Multiple studies have identified metabolic changes within the tumor and its microenvironment during carcinogenesis. Yet, mechanisms by which tumors affect host metabolism are unclear. We find that systemic inflammation induced cancer leads to liver infiltration of myeloid cells at early extrahepatic The infiltrating immune via IL6–pSTAT3 immune–hepatocyte cross-talk cause depletion a master regulator, HNF4α, consequently leading promote breast pancreatic proliferation worse outcome....
Abstract Cancer-associated cachexia (CAC) is a wasting syndrome present in 80% of advanced cancer patients. CAC decreases the quality life, causes higher mortality, and resistance to treatments with increased toxicity. currently incurable directly responsible for up 30% all deaths. We find that cancer-induced systemic inflammation disrupts vagal tone via infiltration innate immune cells into brain, involving dorsal motor nucleus hindbrain. This disruption leads CCL2-driven hyperactivation...
<p>Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis</p>
<p>Supplementary Extended Data 1 describes the FACS gating startegy</p>
<p>Supplementary Extended Data 1 describes the FACS gating startegy</p>
<p>Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to liver during breast carcinogenesis</p>
<p>Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis</p>
<p>Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to liver during breast carcinogenesis</p>
<p>Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth</p>
<p>Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth</p>
<p>Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the PDAC mice</p>
<p>Supplementary Figure S5 demonstrate the significance of our liver score in predicting outcomes BC and PDAC patients</p>
<p>Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the PDAC mice</p>
<p>Supplementary Figure S5 demonstrate the significance of our liver score in predicting outcomes BC and PDAC patients</p>