A5040092953- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Pharmaceutical Economics and Policy
- Pregnancy and Medication Impact
- Pharmacogenetics and Drug Metabolism
- Protein purification and stability
Inserm
2025
Centre National de la Recherche Scientifique
2025
Aix-Marseille Université
2025
Sanofi (France)
2025
In 2017, the free and open-source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into diverse network of stakeholders committed to advancing solutions for model-informed drug development (MIDD). this context, first Community Conference hosted by Novartis in Basel, Switzerland, on October 7-8, 2024, which gathered over 100 attendees more than 40 institutions. This perspective synthesizes key insights conference.
Interspecies translation of monoclonal antibodies (mAbs) pharmacokinetics (PK) in presence target-mediated drug disposition (TMDD) is particularly challenging. Incorporation TMDD physiologically based PK (PBPK) modeling recent and needs to be consolidated generalized provide better prediction regarding inter-species during preclinical clinical development steps mAbs. The objective this study was develop a generic PBPK translational approach for mAbs using the open-source software (PK-Sim®...