A5076243342- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Fatigue and fracture mechanics
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Semiconductor materials and devices
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- dental development and anomalies
- Welding Techniques and Residual Stresses
- Aortic Disease and Treatment Approaches
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Copper Interconnects and Reliability
- Nuclear and radioactivity studies
Kyushu University
1990-2025
Boehringer Ingelheim (Germany)
2025
National Cancer Center Hospital East
2022-2024
SCREEN (Japan)
2014-2023
Boehringer Ingelheim (Switzerland)
2023
Boehringer Ingelheim (Philippines)
2023
National Cancer Centre Japan
2023
Tokyo-Kita Medical Center
2023
The University of Tokyo
1989-2019
Chiba University
2003-2018
Journal Article Association of Serum Antithyroid Antibodies with Lymphocytic Infiltration the Thyroid Gland: Studies Seventy Autopsied Cases Get access HIROSHI YOSHIDA, YOSHIDA 1Department Pathology I, School Medicine, Iwate Medical University, Morioka; and Central Laboratory for Clinical Investigation, Osaka University Hospital Osaka, Japan Search other works by this author on: Oxford Academic Google Scholar NOBUYUKI AMINO, AMINO KANICHI YAGAWA, YAGAWA KUNINORI UEMURA, UEMURA MASANOBU...
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB), losartan, decreases SUA level, whereas other ARBs, such candesartan, have no lowering effect. Because the renal transporter (URAT1) important controlling we examined involvement of URAT1 in those differential effects various ARBs on level at clinically relevant concentrations. This study was done by using URAT1-expressing Xenopus...
The physiological function of organic anion transporter OAT2 (SLC22A7) remains unclear, but since transports purine derivatives, it may be involved in renal handling uric acid, the final metabolite derivatives. In present study, we studied acid transport stably OAT2-expressing HEK293 cells (HEK293/OAT2). mediated uptake, not efflux, [14C]uric acid. Uric was saturable with Km 1168±335 μM (mean and S.E.M.) Vmax 2.57±0.350 nmol/min/mg protein. uptake sensitive to Cl− enhanced at acidic pH....
In 2017, the free and open-source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into diverse network of stakeholders committed to advancing solutions for model-informed drug development (MIDD). this context, first Community Conference hosted by Novartis in Basel, Switzerland, on October 7-8, 2024, which gathered over 100 attendees more than 40 institutions. This perspective synthesizes key insights conference.
The incidence of mucous and ciliated cells in epithelial linings was examined among odontogenic inflammatory cysts (radicular cysts) developmental (dentigerous primordial cysts). Mucous were found 20.8% all examined, while 11.4%; however, always accompanied by cells. radicular dentigerous that higher the maxilla than mandible, mandible maxilla. present results regarding intraosseous indicate a metaplasic origin, but cause biological significance this phenomenon is not known. surface layer...
For diagnosis of very small lesions breast cancer on early stage, a dedicated positron emission tomography (PET) scanner consisting four-layer depth interaction (DOI) detectors is now under development. We are aiming for the spatial resolution less than 1 mm across large effective field view (FOV), and acquisition time 5 minutes each 10 in total. The "C" shape this allows it to be positioned closely around breast, effectively increasing both sensitivity. C-shaped design accommodates variety...
Abstract Bone morphogenetic proteins (BMPs) are crucial factors of osteogenesis. We investigated the expressions BMP subtypes in human salivary adenocarcinoma cell line (HSG‐S8), tongue squamous (HSC‐4) and gingival (Ca9‐22) carcinoma lines, gastric poorly differentiated adenocacinoma (MNK45) signet ring (KATOIII) rectal (RCM‐1, RCM‐2, RCM‐3), thyroid (8505C) bladder (T24) lines by reverse transcription‐polymerase chain reaction (RT‐PCR). RT‐PCR disclosed that BMP‐1 was expressed all...
Bosentan is a substrate of hepatic uptake transporter organic anion-transporting polypeptides (OATPs), and undergoes extensive metabolism by cytochrome P450 (P450), namely, CYP3A4 CYP2C9. Several clinical investigations have reported nonlinear relationship between bosentan doses its systemic exposure, which likely involves the saturation OATP-mediated uptake, P450-mediated metabolism, or both in liver. Yet, underlying causes for pharmacokinetics are not fully delineated. To address this, we...
The localization of bone morphogenetic protein (BMP)‐1, ‐2, ‐3 and transforming growth factor (TGF)‐β in normal salivary gland pleomorphic adenoma the has been examined immunocytochemically. Tumor cells with BMP immunostaining were associated some solid cellular tubuloglandular patterns, stellate myxoid area. In addition, chondroid area three adenomas, chondrocyte‐like positive for BMPs. It is speculated that BMPs secreted by tumor play a role formation component inducing cells, probably...
Background: Although it is known that retinoic acid (RA) regulates the cellular differentiation of skin keratinocytes, effects RA on anchoring junction have not been clarified. The all‐ trans cell–cell and cell–matrix connections gingival epithelial (GE)1 cells in a multilayered culture were investigated. Methods: Ultrastructures GE1 observed immunohistochemistry was used to detect keratin 4, 13, desmoglein expression. Reverse transcription‐polymerase chain reaction performed expression...
L-Citrulline has diagnostic potential for renal function, because its plasma concentration increases with the progression of failure. Although L-citrulline extracted by glomerular filtration in kidney is mostly reabsorbed, mechanism involved not clearly understood. The present study was designed to characterize transport across apical membranes epithelial tubular cells, using primary-cultured rat proximal as well human cell line HK-2. transported a Na(+)-dependent manner from side both types...
The author experienced a case of subacute thyroiditis (de Quervain) in 36-year-old female. Electron microscopic examination the thyroid tissue patient revealed virus-like particles (VLP) degenerated follicular epithelium Judging from size, VLP corresponded to influenza or mumps virus.