A5102779945- Plant Virus Research Studies
- Photosynthetic Processes and Mechanisms
- Plant-Microbe Interactions and Immunity
- Plant Reproductive Biology
- RNA Interference and Gene Delivery
- Plant Parasitism and Resistance
- Mycorrhizal Fungi and Plant Interactions
- Virus-based gene therapy research
- Plant and animal studies
- Peptidase Inhibition and Analysis
- Crop Yield and Soil Fertility
- Plant Ecology and Soil Science
- Wheat and Barley Genetics and Pathology
- Meat and Animal Product Quality
- Plant Disease Resistance and Genetics
- HER2/EGFR in Cancer Research
- Natural Products and Biological Research
- Agriculture, Plant Science, Crop Management
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Biochemical Analysis and Sensing Techniques
- Phytoplasmas and Hemiptera pathogens
- Advanced Chemical Sensor Technologies
- Sugarcane Cultivation and Processing
- Chemical Synthesis and Analysis
Beijing Academy of Agricultural and Forestry Sciences
2023-2025
Chinese Academy of Sciences
2023
Sarepta Therapeutics (United States)
2020-2021
Hunan Agricultural University
2020
Nanjing University
2013
Abstract Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates fill such a role, but their challenging synthesis limits widespread application. To rapidly prototype potential PMO drug candidates, we report fully automated flow-based oligonucleotide synthesizer. Our optimized platform reduces coupling times by...
The antisense phosphorodiamidate morpholino oligomer (PMO) drugs Eteplirsen and Golodirsen are improving the lives of some Duchenne muscular dystrophy (DMD) patients, but treating all DMD subtypes would require development over 50 novel therapies. To rapidly prototype personalized PMO for diseases such as DMD, we designed a fully automated flow-based oligonucleotide synthesizer. Our optimized high temperature synthesis platform reduces coupling times by up to 22-fold compared previously...
Abstract Male sterility enables reduced cost and high seed purity during hybrid production. However, progress toward its commercial applicationhas been slow in tomato due to the disadvantages of most natural male-sterile mutants. Here, we developed a practical method for efficient production using male sterile system with visible marker, which was rapidly generated by CRISPR/Cas9-mediated gene editing. Two closely linked genes, TM6 DFR , were reported be candidates ms15 ( sterile-15 ) aw...