A5030763743- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Platelet Disorders and Treatments
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Reinforcement Learning in Robotics
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- Cellular Mechanics and Interactions
- Genetic and rare skin diseases.
- Exercise and Physiological Responses
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Dermatological and Skeletal Disorders
- Biomedical and Engineering Education
- Cell Adhesion Molecules Research
- Nail Diseases and Treatments
University of California, Davis
2022-2024
University of Illinois Chicago
2010-2022
Captain James A. Lovell Federal Health Care Center
2016-2022
University of Illinois Urbana-Champaign
2008-2022
Chinese University of Hong Kong
2004-2021
University of California, Berkeley
2019-2021
Jesse Brown VA Medical Center
2006-2018
Illinois College
2002-2018
Med Center
2012-2016
University of Illinois System
2013
SUMMARY We investigated cytokine profiles in interleukin (IL)-4 transgenic (Tg) mice with a skin inflammatory disease resembling human atopic dermatitis. cDNA microarray revealed that the mRNAs encoding IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-13, tumour necrosis factor (TNF)-α, TNF-β and interferon (IFN)-γ were up-regulated of late lesion Tg to lesser degree non-lesion when compared those non-Tg mice. Real time reverse transcription–polymerase chain reaction (RT-PCR)...
IL-1 may influence or be influenced by a number of abnormalities present in psoriasis; including keratinocyte proliferation, eicosanoid production, fibroblast activation, endothelial cell adhesiveness, T infiltration and cyclic nucleotide metabolism, transmembrane signal transduction mechanisms. We assessed regulation normal, uninvolved, involved skin psoriatic patients using immunofluorescence microscopy, sensitive ELISA method to quantitate immunoreactive beta alpha protein levels, the...
The objective of these studies was to characterize the IL-1 inhibitory activity present in normal and psoriatic epidermis from clinically stable lesions. Fractionation epidermal cytosol on a molecular sizing column failed reveal presence bioactivity. However, specific ELISAs indicated that both receptor antagonist (IL-1ra) alpha were overlapping peaks. Further fractionation by anion exchange chromatography separated two molecules, revealing bioactivity IL-1ra molecule. Similar protein....
ABSTRACT We present the largest optical photometry compilation of gamma-ray bursts (GRBs) with redshifts (z). include 64813 observations 535 events (including upper limits) from 28 February 1997 to 18 August 2023. also a user-friendly web tool grbLC which allows users visualize photometry, coordinates, redshift, host galaxy extinction, and spectral indices for each event in our database. Furthermore, we have added Gamma-ray Coordinate Network (GCN) scraper that can be used collect data by...
Bullous systemic lupus erythematosus is a generalized subepidermal blistering skin eruption in patients suffering from erythematosus. Type VII collagen was initially identified as the target antigen.We studied an unusual patient who had bullous crythematosus. The fulfilled criteria of with antinuclear antibody titer 1:5120. Immunopathological testing revealed vivo deposition all IgG subclasses, secretory IgA1, and both light chains at patient's basement membrane. vivo-bound IgA were...
We characterized basement membrane zone (BMZ) autoantigens targeted by autoantibodies (AAb) from patients with cicatricial pemphigoid. Serum a patient severe oral pemphigoid contained IgG anti-BMZ AAb. The AAb labeled lower BMZ component on salt-split skin and localized to the lamina lucida/lamina densa direct indirect immunoelectron microscopy (IEM) but did not label blood vessels. react EHS laminin-1 type IV collagen, pepsinized human recombinant entactin, or NC1 domain of VII collagen dot...
<h3>• Background and Design.—</h3> There is much confusion in the clinical classification of immune-mediated subepithelial blistering diseases mucous membranes. We conducted a 6-year comprehensive study to better classify this heterogeneous disease group. Indirect immunofluorescence was performed on salt-split-skin substrate detect circulating antibasement membrane antibodies (n=47). Serologic reactivity against cultured keratinocyte antigens examined by immunoblots (n=38)...