A5087363455- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Immune cells in cancer
- T-cell and B-cell Immunology
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Cystic Fibrosis Research Advances
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Animal Disease Management and Epidemiology
VIB-UGent Center for Inflammation Research
2013-2024
Ghent University Hospital
2012-2024
Ghent University
2012
Inducible bronchus-associated lymphoid tissue (iBALT) is a long lasting tertiary that can be induced following influenza A virus (IAV) infection. Previous studies have shown iBALT structures containing germinal center (GC) B cells protect against repeated infection by contributing locally to the cellular and humoral immune response. If we are exploit this in vaccination strategies, need better understanding on how induced. One hypothesis strength of initial innate response dictates induction...
The phenotypic and functional dichotomy between IRF8+ type 1 IRF4+ 2 conventional dendritic cells (cDC1s cDC2s, respectively) is well accepted; it unknown how robust this under inflammatory conditions, when additionally monocyte-derived (MCs) become competent antigen presenting (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression the Fc receptor CD64 shared with MCs IRF8 cDC1s. These (inf-cDC2s) were superior inducing...