A5033176959- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Protease and Inhibitor Mechanisms
- Digestive system and related health
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- AI in cancer detection
Oulu University Hospital
2023-2025
University of Oulu
2023-2025
Abstract Micropapillary colorectal adenocarcinoma is a morphologic subtype of cancer (CRC) with insufficiently characterized prognostic significance and biological features. We analyzed the histopathological, immunological, features micropapillary in two independent CRC cohorts ( N = 1,876). found that adenocarcinomas accounted for 4.9% 6.4% CRCs cohorts. A growth pattern was associated advanced stage lymphovascular invasion p < 0.001), but also shorter overall survival these factors...
Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not described sufficient detail introduce tumor into clinical use. To study the potential of as a indicator criteria for 3 were defined: average percentage method (tumor whole tumor), hotspot single hotspot), and linear (the diameter largest necrotic focus). Cox regression models used calculate cancer-specific mortality hazard ratios (HRs) categories 2 cancer...
<title>Abstract</title> Colorectal cancer, the second most fatal malignancy globally, burdens public healthcare systems. AI-assisted cancer diagnostics could enable significant cost savings. This study presents a multi-scale ensemble model for DNA mismatch repair deficiency (dMMR) detection from Whole Slide Images (WSIs). dMMR is clinically important feature, traditionally identified through labor- and time-intensive analysis. The prediction capability of non-tumorous regions was also...
Abstract Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is a multifaceted, cytokine-like bioactive molecule whose levels are elevated in wide range inflammatory diseases and associated with prognosis. Additionally, TIMP1 may play role driving systemic inflammation. immunohistochemistry serum concentrations were analyzed cohort 776 colorectal cancer patients. histoscore by cell type (tumor cell, other) was quantified using digital image analysis. Serum evaluated for correlations tumor...
Abstract Background The production of extracellular mucus and expression mucins are commonly aberrant in colorectal cancer, yet their roles tumour progression remain unclear. Methods To investigate the potential influence on immune response prognosis, we analysed mucinous differentiation (non-mucinous, 0%; component, 1–50%; mucinous, >50%) its associations with cell densities (determined three multiplex immunohistochemistry assays or conventional immunohistochemistry) survival 1049 cancer...
Abstract Background Caudal-type homeobox 2 (CDX2) and special AT-rich sequence-binding protein (SATB2) are transcription factors playing important roles in intestinal homeostasis participating the regulation of inflammation. In colorectal cancer (CRC), reduced expression levels CDX2 SATB2 have been associated with poor differentiation worse survival. However, their prognostic significance still needs further clarification, associations between immune cell infiltration into CRC...
Abstract Background SARIFA (Stroma AReactive Invasion Front Areas), defined as the direct contact between a tumour cell cluster and adipose cells at invasion margin, has been proposed prognostic marker in gastrointestinal cancers. We hypothesized that is associated with an immunosuppressive microenvironment. Methods status was evaluated two large colorectal cancer cohorts ( N = 1876). Survival analyses were performed using multivariable Cox regression. Immune densities analysed utilizing...
Abstract Purpose: While the association between cytotoxic T lymphocytes and favorable prognosis in colorectal cancer is well established, prognostic significance of B remain more ambiguous. This study aimed to assess characteristics various cell plasma subsets tumors. Experimental Design: We designed a seven-plex immunohistochemistry assay, combined with machine learning-based image analysis, identify populations applied it cohort 912 assessed densities using Kaplan-Meier estimators Cox...
Tumor budding (TB) is an independent predictor of adverse prognosis in colorectal cancer (CRC), defined as clusters fewer than 5 tumor cells at the invasive margin cancer. According to international consensus criteria (ITBCC), TB should be evaluated from non-mucinous regions. However, some tumors also contain bud-like structures within extracellular mucin pools, and prognostic impact these remains unclear. To assess this, we a modified variable (TB-Muc), representing highest number...
Abstract Background Colorectal cancer (CRC) causes the second most deaths worldwide, but disease course varies according to tumour characteristics and immunological factors. Our objective was examine associations of necrosis with characteristics, immune cell infiltrates, serum cytokine concentrations, as well prognosis in CRC. Methods Three independent CRC cohorts, including 1413 patients, were analysed. Associations areal percentage clinicopathologic parameters, infiltrating cells,...